Coronary artery diseaseDiagnostic Accuracy of 64-Slice Multislice Computed Tomography in the Noninvasive Evaluation of Significant Coronary Artery Disease
Section snippets
Patients and study protocol
The study group consisted of 61 patients who were scheduled for conventional coronary angiography. In addition, MSCT coronary angiography was performed. Patients with contraindications to MSCT were excluded.5 Conventional catheter-based coronary angiography was performed before or after MSCT and served as the reference standard. All patients gave written informed consent to the study protocol, which was approved by the local ethics committee.
Data acquisition
MSCT was performed using a Toshiba Multi-Slice
Patient characteristics
In total, 61 consecutive patients (46 men, 15 women; average age 60 ± 11 years) were included. The average interval between MSCT and conventional angiography was 49 ± 61 days. In 1 patient, the heart rate increased to >90 beats/min during MSCT, rendering the complete data set uninterpretable. The characteristics of the remaining 60 patients are listed in Table 1. In total, CAD was suspected in 25 patients (42%), whereas it was known in 35 patients (58%). A total of 44 stented segments was
Discussion
On a segmental level, a diagnostic accuracy of 97% was observed. It is important that only 12 segments (1%) could not be evaluated for the presence or absence of significant lesions because of insufficient image quality. In addition, an excellent specificity of 98% was observed, with a somewhat lower sensitivity of 85%, on a segmental basis. Nonetheless, from a clinical point of view, data regarding the performance on a patient rather than a segmental basis are preferred, because the selection
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Dr. Schuijf was financially supported by Grant 2002B105 from The Netherlands Heart Foundation. Dr. Pundziute was financially supported by a Training Fellowship of the European Society of Cardiology and the Huygens Scholarship, The Hague, The Netherlands. Dr. Jukema was supported by Grant 2001D032 from the The Netherlands Heart Foundation, The Hague, The Netherlands.