MiscellaneousRelation of Increase in Adiposity to Increase in Left Ventricular Mass from Childhood to Young Adulthood
Section snippets
Methods
This study was approved by the Committee for the Use of Human Subjects in Research at the University of Minnesota. Informed consent was obtained from participants and their parents when the subjects were <18 years of age and from the participants ≥18 years of age. The participants were recruited in 1985 and 1986 after blood pressure screening of 19,452 (93% of all eligible) fifth to eighth grade students in the Minneapolis and St. Paul, Minnesota, public schools. All black, white, and Hispanic
Results
In this longitudinal study, 132 healthy patients (64 males, 68 females; 118 white) were examined at mean ages of 13 and 27 years. The clinical data of the cohort are listed in Table 2. There was a significant increase in body mass index (BMI) from 13 to 27 years. Systolic and diastolic blood pressure increased significantly from 13 to 27 years. Mean LV mass indexed for height2.7 (LV mass index) and diastolic dimensions of the LV cavity, posterior wall, and septum also increased significantly
Discussion
This longitudinal study from age 13 to 27 years examined the impact of adiposity on LV mass and the relation of LV mass to insulin resistance and metabolic syndrome. The results show that BMI and LV mass are significantly related in childhood and track into adulthood, but the association of LV mass with adiposity is considerably stronger in adulthood than in childhood. The degree of increase in LV mass from childhood to young adulthood is related to the degree of increase in BMI, independent of
References (25)
- et al.
Left ventricular mass and body size in normotensive children and adultsassessment of allometric relations and impact of overweight
J Am Coll Cardiol
(1992) - et al.
Insulin resistance syndrome in childhoodassociations of the euglycemic insulin clamp and fasting insulin with fatness and other risk factors in 357 clamp studies
J Pediatr
(2001) - et al.
Association of echocardiographic left ventricular mass with body size, blood pressure and physical activitythe Framingham Study
Am J Cardiol
(1990) - et al.
Relation of blood pressure and body build to left ventricular mass in normotensive and hypertensive employed adults
J Am Coll Cardiol
(1988) - et al.
Association of fasting blood sugar level, insulin level, and obesity with left ventricular mass in healthy children and adolescentsthe Bogalusa Heart Study
Am Heart J
(1999) - et al.
Relation of insulin resistance and body composition to left ventricular mass in children
Am J Cardiol
(2002) - et al.
Obesity, insulin resistance, type 2 diabetes and cardiovascular risk in children. A statement of health professionals from the Committee on Atherosclerosis, Hypertension and Obesity in Youth, of the Council on Cardiovascular Disease in the Young, American Heart Association
Circulation
(2003) - et al.
Sex-specific determinants of increased left ventricular mass in the Tecumseh blood pressure study
Circulation
(1994) - et al.
Factors affecting left ventricular mass in childhoodthe Muscatine Study
Pediatrics
(1993) - et al.
Effect of body size, ponderosity and blood pressure on left ventricular growth in children and young adults in the Bogalusa Heart Study
Circulation
(1995)
Increased left ventricular mass in obese adolescents
Eur Heart J
Left ventricular structure and function in obese adolescentsrelations to cardiovascular fitness, percent body fat, and visceral adiposity, and effects of physical training
Pediatrics
Cited by (64)
Childhood Risk Factors and Adulthood Cardiovascular Disease: A Systematic Review
2021, Journal of PediatricsCitation Excerpt :One article had a null finding, where overweight in early childhood (ages 2-11 years) was not associated with cIMT in older adulthood.29 The association between greater childhood adiposity and adverse adulthood left ventricular (LV) structure and function was significant across 11 articles.15,30-39 One study examined the association of BMI in adolescence and presence of adult coronary artery calcification, finding a positive association.40
Adiposity, Sex, and Cardiovascular Disease Risk in Children With CKD: A Longitudinal Study of Youth Enrolled in the Chronic Kidney Disease in Children (CKiD) Study
2020, American Journal of Kidney DiseasesAutophagy as a therapeutic target for cardiovascular complications in obesity-concepts, controversies, and challenges
2018, Autophagy and Cardiometabolic Diseases: From Molecular Mechanisms to Translational MedicineInsulin resistance, serum uric acid and metabolic syndrome are linked to cardiovascular dysfunction in pediatric obesity
2017, International Journal of CardiologyEpigenetics and obesity cardiomyopathy: From pathophysiology to prevention and management
2016, Pharmacology and TherapeuticsCitation Excerpt :Uncorrected obesity is closely linked to cardiac remodeling accompanied by structural and functional abnormalities (Bonow & Eckel, 2003; Eckel, 2008). Increased left ventricular (LV) mass is seen in obese individuals displaying a positive correlation with BMI (Sivanandam et al., 2006). Interestingly, the strength in the association between LV mass and BMI rises with biological age (Sivanandam et al., 2006).
This study was supported by Grants HL 04000-05, HL 52851, and M01 RR00400 from the National Institutes of Health, Bethesda, Maryland. Dr. Sivanandam was partially funded by the Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota, as a Lillehei Scholar for the duration of this project.