MiscellaneousPrevalence and Correlates of Septal Delayed Contrast Enhancement in Patients With Pulmonary Hypertension†
Section snippets
Methods
The study population consisted of 72 patients referred for cardiac magnetic resonance evaluation of known or suspected PH (September 2004 to March 2006) who additionally underwent right-sided cardiac catheterization. All patients gave informed consent for the procedures, and the study was approved by the institutional review board. Criteria of exclusion from the analysis were time interval between magnetic resonance and catheterization >3 months and DCE in areas other than the septal RV
Results
After the exclusion of 10 patients with time intervals between cardiac magnetic resonance and catheterization >3 months, 5 patients with DCE in other areas (4 with previous myocardial infarctions and 1 with diffuse cardiac sarcoidosis), and 2 patients who refused to receive contrast agents, the final study population consisted of 55 patients. They were predominantly women (33 [60%]), with a mean age of 50 years (range 29 to 88). The median time interval between examinations was 0 days (mean
Discussion
The main findings of this investigation are as follows: (1) DCE in the septum at the level of the RV insertion points is extremely common in patients with chronic PH of different causes; (2) the extent of DCE correlates with the degree of hemodynamic and RV morphofunctional impairment; and (3) in multivariate analysis, systolic pulmonary pressure is the only predictor of DCE.
In this study, the prevalence of DCE was very high in patients with confirmed PH at rest. There were also 2 subjects with
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Conflict of interest: Dr. O’Donnell is an employee of Siemens Corporate Research, Princeton, New Jersey.