Valvular heart diseaseFactors Influencing Left Ventricular Structure and Stress-Corrected Systolic Function in Men and Women With Asymptomatic Aortic Valve Stenosis (a SEAS Substudy)
Section snippets
Study population
The present substudy was prospectively planned within the SEAS study that enrolled 1,873 European patients with asymptomatic AS, defined by echocardiography at local study centers as aortic valve thickening and peak transaortic Doppler velocity ≥2.5 and ≤4 m/s. Patients were randomized from January 2001 to February 2004 in 173 hospitals in Norway, Sweden, Finland, Denmark, United Kingdom, Ireland, and Germany to 4-year placebo-controlled combined treatment with ezetimibe 10 mg/day and
Clinical and hemodynamic characteristics
In total 1,046 men and 674 women were included in the present analysis. Women were older, included more obese and hypertensive patients, and had a smaller aortic valve area index (Table 1, Table 2). Prevalence of treated hypertension and type of antihypertensive medication did not differ between men and women. Mitral regurgitation was of grade 1 in 38% and grade 2 in 8% of men and grade 1 in 39%, grade 2 in 13%, and grade 3 in 1% of women (p <0.001). Aortic regurgitation was grade 1 in 45%,
Discussion
Only few studies including a limited number of patients have previously assessed the influence of gender on LV structure and function in patients with mild to moderate asymptomatic AS.17, 18 Thus, the present results add to current knowledge by (1) demonstrating that gender independently influences LV geometry also in patients with mild or moderate asymptomatic AS; (2) identifying partly different covariates of LV hypertrophy in men and women; and (3) demonstrating that gender-related
References (29)
- et al.
Impact of chamber geometry and gender on left ventricular systolic function in patients >60 years of age with aortic stenosis
Am J Cardiol
(1994) - et al.
Design and baseline characteristics of the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study
Am J Cardiol
(2007) - et al.
Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings
Am J Cardiol
(1986) - et al.
Effect of growth on variability of left ventricular mass: assessment of allometric signals in adults and children and their capacity to predict cardiovascular risk
J Am Coll Cardiol
(1995) - et al.
Association of carotid atherosclerosis and left ventricular hypertrophy
J Am Coll Cardiol
(1995) - et al.
Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension
J Am Coll Cardiol
(1992) - et al.
Assessment of left ventricular function by the midwall fractional shortening/end-systolic stress relation in human hypertension
J Am Coll Cardiol
(1994) Valvular aortic stenosis: disease severity and timing of intervention
J Am Coll Cardiol
(2006)- et al.
Prevalence and correlates of aortic regurgitation in American Indians: the Strong Heart Study
J Am Coll Cardiol
(2000) - et al.
Prevalence and correlates of mitral regurgitation in a population-based sample (the Strong Heart Study)
Am J Cardiol
(2001)
Gender differences in left ventricular function at rest and with exercise in asymptomatic aortic stenosis
Am Heart J
Gender differences in systolic left ventricular function in hypertensive patients with electrocardiographic left ventricular hypertrophy (the LIFE study)
Am J Cardiol
Comparison of cardiac structure and function in American Indians with and without the metabolic syndrome (the Strong Heart Study)
Am J Cardiol
Assessment of left ventricular function by meridional and circumferential end-systolic stress/minor-axis shortening relations in dilated cardiomyopathy
Am J Cardiol
Cited by (0)
The Simvastatin Ezetimibe in Aortic Stenosis (SEAS) echocardiography core laboratory was supported by MSP Singapore Company, LLC, Singapore, a partnership between Merck Co. Inc. and the Schering-Plough Corporation.