Preventive cardiologyRelation of Educational Level to Inflammation-Sensitive Biomarker Level
Section snippets
Methods
We analyzed data collected through the Tel-Aviv Medical Center Inflammation Survey (TAMCIS), a registered data bank of the Israeli Ministry of Justice.2, 3, 4, 5, 6, 7, 8 This relatively large survey was composed of apparently healthy persons attending the medical center for periodic health examinations.
All patients attending the Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel, for routine health examinations from September 2002 to November 2007 were invited to participate in the TAMCIS.
Results
We analyzed data for 8,998 subjects (5,757 men, 3,241 women) with a mean age of 44 ± 11 years (range 18 to 84). Anthropometric characteristics, blood pressure, relevant laboratory studies, inflammation-sensitive biomarkers, sport activity, and alcohol consumption habits of both genders are listed in Table 1, Table 2 according to tertiles of educational level for men and women, respectively. Various cardiovascular risk factors and frequencies of relevant drug intake for both genders are listed
Discussion
We analyzed the association between level of education and inflammation-sensitive biomarkers and prevalence of cardiovascular risk factors in a large sample of apparently healthy, asymptomatic, highly educated subjects. About of the subjects in our sample had >14 years of schooling and about ⅓ declared ≥17 years of schooling. No previous large-scale data exist for this type of population. We analyzed this subpopulation with the a priory assumption of a higher educational level. Our results,
References (30)
- et al.
Values of high-sensitivity C-reactive protein in each month of the year in apparently healthy individuals
Am J Cardiol
(2005) - et al.
The effect of ethnic origin on pulmonary prediction equations in a Jewish immigrant population
Respir Med
(2008) - et al.
Short-term exposure to air pollution and inflammation-sensitive biomarkers
Environ Res
(2008) - et al.
C-Reactive protein levels among women of various ethnic groups living in the United States (from the Women's Health Study)
Am J Cardiol
(2004) - et al.
Relation of low socioeconomic status to C-reactive protein in patients with coronary heart disease (from the Heart and Soul Study)
Am J Cardiol
(2005) - et al.
Social and psychosocial influences on inflammatory markers and vascular function in civil servants (the Whitehall II study)
Am J Cardiol
(2003) - et al.
The association between educational status and risk factors related to cardiovascular disease in healthy individuals: The ATTICA Study
Ann Epidemiol
(2004) - et al.
Associations of low formal education level and poor health status: behavioral, in addition to demographic and medical, explanations?
J Clin Epidemiol
(1994) - et al.
Income inequality a determinant of population health?Part 1. A systematic review
Milbank Q
(2004) - et al.
Lack of significant effect of low doses of aspirin on the concentrations of C-reactive protein in a group of individuals with atherothrombotic risk factors and vascular events
Blood Coagul Fibrinolysis
(2006)
Heart rate and microinflammation in men: a relevant atherothrombotic link
Heart
Glycohaemoglobin as a determinant of increased fibrinogen concentrations and low-grade inflammation in apparently healthy nondiabetic individuals
Clin Endocrinol (Oxf)
Determinants of the erythrocyte sedimentation rate in the era of microinflammation: excluding subjects with elevated C-reactive protein levels
Am J Clin Pathol
C-Reactive protein as a screening test for cardiovascular risk in a multiethnic population
Arterioscler Thromb Vasc Biol
Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens
Acta Haematol Basel
Cited by (33)
Socioeconomic disparity in cardiovascular disease: Possible biological pathways based on a proteomic approach
2022, AtherosclerosisCitation Excerpt :We further explored whether there was a pattern linking education to specific biological pathways by studying predefined pathways separately. From previous work [13–15], inflammation/immune response, platelet activation/cell adhesion and MAPK cascade were of significant interest. Educational attainment was associated with multiple biomarkers in all three biological pathways (Fig. 2).
Patterning of educational attainment across inflammatory markers: Findings from a multi-cohort study
2020, Brain, Behavior, and ImmunityCitation Excerpt :Our findings are in agreement with data-driven analyses on diseases across all organ systems that have linked low SEP to increased risk of health conditions characterized by elevated systemic inflammation, such as diseases of the pancreas, liver, kidney, vascular and respiratory system, lung cancer, and dementia (Kivimäki et al., 2020). In line with a number of studies on inflammatory markers, our results support studies reporting an association between disadvantaged SEP and high CRP levels (Nazmi and Victora, 2007; Muscatell et al., 2018) and further add to the empirical evidence supportive of the social patterning of fibrinogen (Davillas et al., 2017; Panagiotakos et al., 2004; Pollitt et al., 2008; Steinvil et al., 2008). The weaker association observed between educational attainment and IL-6 is in contrast with another recently published meta-analysis that reported a social gradient for IL-6 (Muscatell et al., 2018).
Burnout, but not job strain, is associated with irritable bowel syndrome in working adults
2020, Journal of Psychosomatic ResearchCitation Excerpt :The HC group was selected from working individuals who came to the Center for Periodic Health Examination at Tel Aviv Sourasky Medical Center for routine health examinations, and voluntarily agreed to participate in a Tel Aviv Medical Center Inflammation Survey (TAMCIS) cohort study. Participants gave their written consent in accordance with the guidelines of the Institutional Ethics Committee (n = 12,251) [36]. We randomly selected 1000 participants among the participants in the TAMCIS study to achieve a patient/control ratio of 1:4.
Impacts of low socioeconomic status and polycyclic aromatic hydrocarbons exposure on lung function among a community-based Chinese population
2017, Science of the Total EnvironmentCitation Excerpt :A review indicated that socioeconomic position has been shown to be an effect-modifier of the association between air pollution and children's asthma exacerbations (Rodriguez-Villamizar et al., 2016). Additionally, studies revealed that neighborhood SES modified the association between individual smoking status and levels of PAH-DNA adduct in prostate tissue when reactive PAH metabolites covalently bind with DNA (Rundle et al., 2012) and low educational levels were associated with a higher level of inflammation (Steinvil et al., 2008). A recent study suggested that chronic air pollution exposure was associated with lung function decline among adults in Europe (Adam et al., 2015).