Preventive CardiologyRelation of Black Race Between High Density Lipoprotein Cholesterol Content, High Density Lipoprotein Particles and Coronary Events (from the Dallas Heart Study)
Section snippets
Methods
The Dallas Heart Study (DHS) is a multiethnic, probability-based, population cohort study of Dallas County residents, with deliberate oversampling of black participants. The study design has been extensively described previously.3 Briefly, from 2000 to 2002, 2,971 participants completed a detailed in-home survey, laboratory testing, and imaging studies. For the present study, the study population comprised 1,977 participants who, at study entry, were not taking any lipid-lowering medications or
Results
The study comprised 1,977 adult participants; 51% were women, and 46% were black. Among men, blacks had highest median HDL-C and HDL-P and the largest median HDL particle size (Table 1). However, the magnitudes of the differences in median HDL-P (2%) and HDL particle size (3%) were smaller than those for HDL-C (17%). Among women, white women had the highest median HDL-C and HDL-P (Table 1). Unlike black men, black women had discordant HDL composition compared with white women (similar median
Discussion
In a large multiethnic, population-based cohort, we describe for the first time that factors that associate with levels of HDL-P, a novel marker of HDL composition, vary significantly from those that associate with HDL-C in an ethnicity- and gender-specific manner. This is also the first report to show that HDL-P is inversely associated with prevalent coronary calcium in the general population. In addition, we demonstrate that black ethnicity modifies the association between HDL-C and incident
Disclosures
Dr. McGuire has received consulting income from F. Hoffmann LaRoche, Genentech, Sanofi-Aventis, Daiichi Sankyo, Novo Nordisk, and Tethys Bioscience. Dr. Rohatgi has received grant support from Merck and is on the speaker’s bureau of AstraZeneca.
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Cited by (34)
The benefits of measuring the size and number of lipoprotein particles for cardiovascular risk prediction: A systematic review and meta-analysis
2023, Clinica e Investigacion en ArteriosclerosisRace-Dependent Association of High-Density Lipoprotein Cholesterol Levels With Incident Coronary Artery Disease
2022, Journal of the American College of CardiologyCitation Excerpt :Most evidence stems from ethnically White-enriched cohorts; therefore, it is unknown whether the U-shaped association applies to all races and ethnicities. In the Dallas Heart Study, with 46% Black participants, HDL-C was inversely associated with incident CHD among non-Black but not in Black participants.25 A prior analysis in a cancer-focused REGARDS substudy did report that HDL-C of 30 to 40 mg/dL—compared with HDL-C >40 mg/dL—was associated with lower CHD risk in Black but not in White adults, but did not report on the association of all established HDL-C clinical categories with CHD risk.26
Sex and Racial Differences in High-Density Lipoprotein Levels in Acute Coronary Syndromes
2021, American Journal of the Medical SciencesCholesterol efflux capacity, HDL cholesterol, and risk of coronary heart disease: A nested case-control study in men
2019, Journal of Lipid ResearchCitation Excerpt :Some recent studies conducted among prospective cohorts free of underlying CVD have reported strong inverse associations between CEC and cardiovascular events even with adjustment for HDL-C (14, 15, 30). For example, in an analysis of the Dallas Heart Study with black participants comprising 49% of the population, Rohatgi et al. (15) reported a 67% lower risk of a mixed cardiovascular endpoint in the highest versus lowest quartile of CEC (0.33; 0.19–0.55), adjusted for HDL-C. Interestingly, HDL-C itself was not strongly inversely associated with risk of CHD in the Dallas Heart Study (15, 31). The strength of HDL-C as a risk factor for CHD has been questioned in individuals of African American descent (31), which may offer a partial explanation for the discrepancy in findings between the Dallas Heart Study CEC analysis and the present study.
High-Density Lipoprotein and High-Density Lipoprotein Cholesterol
2018, Biomarkers in Cardiovascular Disease
The Dallas Heart Study was funded by the Donald W. Reynolds Foundation and was partially supported by the National Center for Advancing Translational Sciences of the National Institutes of Health, Bethesda, Maryland, under Award Number UL1TR001105. Dr. Rohatgi is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Number K08HL118131. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the National Heart, Lung, and Blood Institute.
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