Coronary Artery DiseaseMeta-Analysis of Randomized Trials on Remote Ischemic Conditioning During Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction
Section snippets
Methods
We performed a computerized search of the Medline, Cochrane, and Web of Science databases without language restrictions up to September 2016, using the search terms “remote conditioning” or “remote preconditioning” or “remote postconditioning” or “remote perconditioning” or “remote ischemic conditioning” or “remote ischemic preconditioning” or “remote ischemic postconditioning” or “remote ischemic perconditioning” in patients with myocardial infarction. Abstracts of the major scientific
Results
Study selection process is described in the flow diagram (Figure 1). Eight studies met our inclusion criteria including a total of 1,083 patients. Seven studies were retrieved from Medline database,3, 4, 5, 20, 21, 22, 23 and one study was presented as an abstract at Society for Cardiac Angiography and Interventions meeting in 2016.24 Data from Boetker et al3 were retrieved from the initial published article and subsequent article reporting 3-year follow-up results of the same study
Discussion
In this meta-analysis of 8 randomized trials including 1,083 patients with STEMI who underwent primary PCI, RIC was associated with reduced IS assessed by biomarker release compared with standard of care. RIC was also associated with better achievement of full STR and lower MACCE rates. There was a nonsignificant reduction in IS assessed by cardiac imaging and no difference in postprocedural TIMI-III flow with RIC technique. Meta-regression analysis showed that increasing the duration of
Disclosures
The authors have no conflicts of interest to disclose.
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