Clinical research studyGout in African Americans
Section snippets
Data Source
Data were made available through the National Heart, Lung, and Blood Institute limited-access program. The Multiple Risk Factor Intervention Trial (MRFIT) participants provided informed consent for data collection and analysis. The Stanford Institutional Review Board approved the present analyses. Dr Krishnan possesses the original data and statistical codes. This study was unsponsored.
Participant Enrollment and Follow-up
From 1973 to 1975, 361,662 men at high risk for coronary artery disease aged 35 to 57 years and free of a
Baseline Characteristics
Of the 12,886 men enrolled in the MRFIT cohort, 11,559 men were Caucasian and 931 men were African American. Details of ethnicity information on the remaining 376 were not available, and thus, these men were excluded, leaving 12,490 men for the present analyses. Table 1 shows the descriptive characteristics of the cohort used in this analysis at the time of baseline visit. There were no statistical differences between ethnicities in terms of prevalence of diabetes, obesity, or mean serum
Discussion
The present study showed that incidence of hyperuricemia and gout in a group of African Americans with high cardiovascular risk was substantially lower than that among Caucasians with a similar risk profile. This difference was not explained by differences in the prevalence of lifestyle or clinical risk factors for gout between these 2 groups. The reduced risk was more marked among selected subgroups of African Americans who did not have obesity or hypertension and who did not use diuretics,
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Funding: The Multiple Risk Factor Intervention Trial (MRFIT) was conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the MRFIT investigators. The present study was performed using a limited-access data set obtained from the NHLBI and does not necessarily reflect the opinions or views of the MRFIT or the NHLBI. ClinicalTrials.Gov Identifier: NCT 00000487.
Conflict of Interest: EK has served as a consultant to Takeda Pharmaceuticals, Inc., URL Pharmaceuticals Inc., Metabolic, Inc., and UCB Pharmaceuticals, Inc., and has received grant support from URL, ARDEA Biosciences, and Takeda. However, these entities did not sponsor this study nor did they have access to the contents before publication.
Authorship: EK was responsible for all aspects of this manuscript from concept to finalizing the manuscript. He serves as the guarantor for this paper. There are no patents, products in development, or marketed products to declare with respect to this manuscript.