North Pacific Surgical AssociationStage III & IV colon and rectal cancers share a similar genetic profile: a review of the Oregon Colorectal Cancer Registry
Section snippets
Patient information, microsatellite instability, and mutation analysis
An institutional review board–approved study was performed, using the Oregon Colorectal Cancer Registry (OCCR). Patient demographics and tumor characteristics, including MSI and mutations for p53, AKT, BRAF, KRAS, MET, NRAS, and PIK3CA, were analyzed in up to 386 patients. Not all patients had every mutation tested. Mutations were tested on the basis of clinical suspicion by the pathologist or medical oncologist.
Tumor specimens and DNA preparation
Blocks of formalin-fixed, paraffin-embedded tumor tissue, or unstained sections of
Demographics
Using the OCCR, we identified 386 potential patients to include in our study. One hundred sixteen patients (31%) had rectal cancer, and 254 (69%) had colon cancer. The status of the remaining 16 patients was indeterminate. Colon cancers were equally distributed between men and women (49% vs 51%), but rectal cancers were more common in men than in women (66% vs 34%). Three hundred forty-five patients were staged, using the 7th edition of the American Joint Committee on Cancer's
Comments
The purpose of this study was to determine whether known genetic mutations associated with colorectal carcinogenesis differ between colon and rectal cancers and if differences were associated with survival independent of stage. Using the OCCR database, we demonstrated that there were no significant differences in the prevalence of MSI and mutations for p53, KRAS, PIK3CA, AKT, MET, and NRAS in stage III and IV colon and rectal cancers. However, similar to studies in early-stage colorectal
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Is sidedness prognostically important across all stages of colorectal cancer?
2016, The Lancet OncologyA perspective on the current treatment strategies for locally advanced rectal cancer
2015, International Journal of Biochemistry and Cell BiologyCitation Excerpt :In other words, rectal and distal colon tumours share similar mutational patterns distinct from those of right/ascending colon tumours. A more recent study also confirmed that advanced stage III and IV colon and rectal cancers share similar molecular profiles, with the exception, as previously reported, of BRAF mutations which are more frequent in colon cancer compared with rectal cancer (Gawlick et al., 2013). An exploratory analysis of clinical correlations by genotype in patients with metastatic colon and rectal cancer also confirmed the prevalence of BRAF mutation in colon cancer but, in addition it also showed for the first time a significant increase in NRAS mutation rate in older patients with rectal cancer; such finding needs to be further investigated (Russo et al., 2014).
Recent Advances on the Differences between Left- And Right-sided Colorectal Cancer
2021, Acta Academiae Medicinae SinicaeUnderstanding and Resetting Radiation Sensitivity in Rectal Cancer
2017, Annals of Surgery
The authors declare no conflicts of interest.