Clinical caseInfant's bilobar thyroid agenesis and mother's I-131 accidental administrationAgénésie thyroïdienne bilobaire chez le nouveau-né après administration accidentelle d’iode-131 pendant la grossesse
Introduction
I-131 has been widely used in nuclear medicine for treatment of Graves’ disease or thyroid cancer. Few reports regarding fetal uptake of radionuclide after radioiodine treatment of pregnant women have been published [1], [2]. There still remain many questions about the clinical outcome of the fetus in this accidental clinical situation. In this paper, we present the case of a woman who received I-131 during and after pregnancy and report the fetal outcome.
Section snippets
Case presentation and discussion
In May 2007, the dosimeter of a female staff member in the department of nuclear medicine reached 9.4 mSv. A urine sample was collected and the gamma spectrum analysis showed that the isotope was I-131. According to ICRP publications and other references [3], [4], we estimated that the total radioactivity of administered I-131 was greater than 10 mCi (9–22 mCi). Further information showed that the woman had an 8-month-old infant who was born at full term, but had no thyroid; both lobes of the
Conclusions
Earlier data also suggested that there is a threshold for radiation effects. But data from Chernobyl fallout did demonstrate an increased risk of thyroid cancer [15]. In this case report, we speculate that I-131 administration during pregnancy may be associated with infant thyroid agenesis. However, bilobar thyroid agenesis is an exceptionally rare phenomenon. Further investigations are needed to determine whether the bilobar thyroid agenesis is inevitable or incidental for this case. In
Disclosure of interest
The authors declare that they have no conflicts of interest concerning this article.
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Cited by (2)
Thyroid hormones, iodine and iodides and antithyroid drugs
2014, Side Effects of Drugs AnnualCitation Excerpt :Compounding factors in this case were use of steroids to treat asthma and deliberate vitamin D deficiency. Fetotoxicity A rare disease of bilobar thyroid agenesis occurred in an infant whose mother was accidentally exposed to 131I during early pregnancy at an estimated dosage 30 mGy (10–12 weeks gestation) [27A]. This dose was lower than previously reported (SEDA-32, 765).
Bilobar thyroid agenesis with primary hyperparathyroidism: report of a case
2015, Surgery Today