Myxofibrosarcoma of the hypopharynx
Introduction
Myxofibrosarcoma is one of the commonest sarcomas in the field of orthopedic surgery. Typically, it grows in the subcutaneous of the extremities of elderly persons. Myxofibrosarcoma in the head and neck region is very rare and only a few cases of the disease in this area have been reported [1], [2], [3]. Most of the malignant tumors in the hypopharynx are carcinomas, and there are some reports of hypopharyngeal sarcomas, such as angiosarcoma, follicular dendritic cell sarcoma, liposarcoma and synovial sarcoma [6], [7], [8], [9]. Here, we report a first case of hypopharyngeal myxofibrosarcoma.
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Case report
A 69-year-old Japanese man had a gastrointestinal fiberscope examination, which he had been receiving every year for the health check-up, by an internal medicine doctor at a municipal hospital in June 2003. The doctor found a tumor in the larynx and consulted an otorhinolaryngologist (ORL). The ORL doctor diagnosed it as a hypopharyngeal tumor and introduced this patient to our hospital. He had been suffering from hypertension for more than 10 years with good control and had a history of brain
Discussion
Myxofibrosarcoma was first proposed by Angervall et al. [10], who described it as a group of fibroblastic lesions which has cellular distribution, pleomorphism of the nucleus, and mitotic activity that varies from a less cellular lesion with minimal cytologic atypia to a more cellular lesion with features similar to those of pleomorphic-storiform malignant fibrous histiocytoma (MFH). Histological findings at low magnification show many nodules with low cellularity. The component cells are
Acknowledgements
We thank Dr. N. Kameda, Department of Pathology, Sakura Hospital, Toho University, Dr. H. Hashimoto, Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Dr. H. Kanda, Department of Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research and Dr. M. Tsuneyoshi, Department of Anatomic Pathology, Graduate School of Medicine, Kyushu University, for pathological diagnose.
References (11)
Central myxofibrosarcoma of the mandible treated by radical resection
Oral Surg Oral Med Oral Pathol
(1975)- et al.
Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems
Hum Pathol
(2004) - et al.
Myxofibrosarcoma of the sphenoid sinus
J Laryngol Otol
(2002) - et al.
Myxofibrosarcoma of the maxillary sinus
Del Med J
(1982) - et al.
Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low-grade variant
Am J Surg Pathol
(1996)