Original articleAdult cardiacEffect of Concomitant Coronary Artery Disease on Procedural and Late Outcomes of Transcatheter Aortic Valve Implantation
Section snippets
Patients and Methods
This study is a retrospective review of data records of 201 patients enrolled in two studies. It was reviewed and approved by the North Texas Institutional Review Board at Medical City Dallas with a waiver of consent.
Between December of 2005 and February of 2008, 201 high-risk patients were enrolled in two feasibility studies utilizing the stainless-steel balloon expandable Sapien valve (Edwards Lifesciences, Irvine, CA) at 12 participating centers in North America and Europe. A total of 40
Results
A total of 201 patients were identified as having undergone attempted TA-AVI (n = 40) or TF-AVI (n = 161) from 12 centers in North America and Europe between December 2005 and February 2008 as part of transapical and transfemoral feasibility trials. In the 40 patient TA-AVI trial, five patients were excluded from analysis due to technical complications that resulted in embolization of the valve or malplacement such that conversion to an open procedure was required. Table 1 characterizes the 35
Comment
It is axiomatic that aortic valve replacement is the treatment of choice for patients with critical aortic stenosis. However, certain patient populations have been excluded from conventional surgical therapy due to perceived elevated operative risk [12, 13]. Transcatheter aortic valve implantation, either retrograde through a transfemoral approach or antegrade through a transapical approach, has become a clinical reality in the treatment of critical aortic stenosis in high-risk patients. Early
References (16)
- et al.
Transapical aortic valve implantation: step by step
Ann Thorac Surg
(2009) - et al.
Percutaneous aortic valve replacement for severe aortic stenosis in high-risk patients using second and current third generation self-expanding CoreValve prosthesis
J Am Coll Cardiol
(2007) - et al.
Reliability of risk algorithms in predicting early and late operative outcomes in high-risk patients undergoing aortic valve replacement
J Thorac Cardiovasc Surg
(2008) - et al.
United States feasibility study of transcatheter insertion of a stented aortic valve by the left ventricular apex
Ann Thorac Surg
(2008) - et al.
Transcatheter aortic valve replacement in patients with critical aortic stenosis: rationale, device description, early clinical experiences, and perspectives
Semin Thorac Cardiovasc Surg
(2006) - et al.
Clinical profile and natural history of 435 nonsurgically managed patients with severe aortic stenosis
Ann Thorac Surg
(2006) - et al.
Multivariate prediction of in-hospital mortality associated with aortic and mitral valve surgery in northern New England
Ann Thorac Surg
(2004) - et al.
Current determinants of operative mortality in 1400 patients requiring aortic valve replacement
Ann Thorac Surg
(2003)
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