Original articleGeneral thoracicExpression of Acetylcholine and Its Receptor in Human Sympathetic Ganglia in Primary Hyperhidrosis
Section snippets
Study Design
We performed a cross-sectional study in which 2 groups were analyzed: the hyperhidrosis (HYP) group, comprising patients with palmar hyperhidrosis who were eligible for thoracic sympathectomy, and the control (CON) group, comprising brain-dead organ donors without a history of hyperhidrosis. This study was approved by the Ethics Committee for Analysis of Research Projects, and all participants (or their legal guardians) provided written consent.
Setting
Ganglia resections in the HYP group were carried
Results
From December 2008 to March 2010, 47 subjects were enrolled. Four subjects were excluded because of a body mass index greater than 25 kg/m2, 2 were excluded because of diabetes, and 1 was excluded because of suspected hyperhidrosis (all them in the CON group). There were no surgical complications or significant delay in the retrieval of other organs (CON group). Similarly, there was no data loss. The median participant age was 26 years (24–30.25 years) in the HYP group and 46.5 years (28.25–53
Comment
Surgical treatment of primary hyperhidrosis by video-assisted thoracic sympathectomy has improved the quality of life in a growing number of individuals worldwide every year. This procedure already accounts for a significant portion of the activity of most thoracic surgery services, yet little is known about the target organ of this operation: the sympathetic ganglion, especially among patients with hyperhidrosis, the subgroup of individuals who will be operated on [1, 3, 4, 14, 15, 16, 17, 18
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