Case reportUreaplasma Transmitted From Donor Lungs Is Pathogenic After Lung Transplantation
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Comment
We recently discovered that Ureaplasma infection causes the highly fatal hyperammonemia syndrome [3], which affects more than 4% of lung recipients and is characterized by sepsis, altered mental status, and progressively elevated serum ammonia [1]. Ureaplasma urealyticum and U. parvum are fastidious commensal organisms found in the urogenital tract in as many as 40% of healthy men and 80% of healthy women [6]. They are often unrecognized pathogens given their inability to grow on routine
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Cited by (44)
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2023, Transplantation ProceedingsRisk factors, management, and clinical outcomes of invasive Mycoplasma and Ureaplasma infections after lung transplantation
2023, American Journal of TransplantationA novel cause of emergent hyperammonemia: Cryptococcal fungemia and meningitis
2021, Molecular Genetics and Metabolism ReportsCitation Excerpt :One of several proposed mechanistic hypotheses has been that urease-producing bacteria of the genitourinary tract may lead to hyperammonemia following lung transplantation due to dissemination in an immunosuppressed state [19,20]. Additionally, hyperammonemia (of 80 μM) was reported in an individual following lung transplantation where the donor had bronchoalveolar lavage positive for U. parvum prior to the procedure [4]. The mechanism of hyperammonemia in lung transplant recipients is still being evaluated, but it may be due to an infectious etiology in an immunocompromised host.