Original articleAdult cardiacHeart-Type Fatty Acid Binding Protein and Ischemia-Modified Albumin for Detection of Myocardial Infarction After Coronary Artery Bypass Graft Surgery
Section snippets
Patients
Between January 2010 and April 2013, a total of 210 patients were prospectively enrolled in the study. Patients were consequently assigned without randomization into two main study groups, cohort A or cohort B. All patients gave written informed consent, and the study was performed with Institutional Ethics Committee approval. All patients more than 18 years of age with double- or triple-vessel coronary artery disease who were scheduled for elective, isolated, primary CABG surgery with
Results
In all, 210 consecutive patients undergoing elective, isolated, primary CABG with cardiopulmonary bypass were enrolled in a prospective study. Figure 1 shows the study design. Of the 210 patients enrolled, 108 patients were allocated to cohort A to investigate hFABP in comparison with cTnI, and 104 patients were allocated to cohort B to investigate IMA in comparison with cTnI in patients with and patients without PMI after CABG. Patients were consecutively allocated without randomization to
Comment
The main results from the present prospective pilot study in two cohorts with a total of 210 multivessel coronary artery disease patients undergoing elective, isolated, on-pump CABG surgery can be summarized as follows.
Heart-type fatty acid binding protein is a sensitive and very early biomarker for myocardial ischemia or infarction, and is significantly elevated in patients with PMI after elective, isolated on-pump CABG. We demonstrated that hFABP not only differentiates with a high level of
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Diagnostic dilemma of perioperative myocardial infarction after coronary artery bypass grafting: A review
2020, International Journal of SurgeryCitation Excerpt :HFABP, in particular, seems to be promising. It rises earlier than Troponin and CK-MB, so myocardial injury can be detected rapidly in the early postoperative phase [28–30]. Jo et al. evaluated the ability of hFABP to discriminate between PMI versus myocardial manipulation during cardiac surgery.
Cardiac Myosin-Binding Protein C Release Profile After Cardiac Surgery in Intensive Care Unit
2019, Annals of Thoracic SurgeryCitation Excerpt :An elevated cTnI level after major noncardiac surgery conferred an increase in mortality during the 7-year follow-up period.17 Recent studies have shown that the postoperative brain natriuretic peptide,15 heart-type fatty acid binding protein,5,18 growth differentiation factor-15,6 and glycosylated hemoglobin19 can be used to detect perioperative myocardial infarction reliably and to improve the prediction of mortality. The cMyBP-C, a 140-kDa protein that resides on the thick filament of the heart muscle, is a major regulatory protein for cross-bridge kinetics and myocardial contraction.20
Cardiac Laboratory Markers
2019, Physician Assistant ClinicsCitation Excerpt :hFABP is primarily found in cardiac myocytes so it is more specific for cardiac myocyte necrosis. One recent trial compared the utility of IMA and hFABP versus cardiac troponin for myocardial infarction after coronary artery bypass grafting.6 This trial showed that hFABP was more sensitive than IMA for detecting postoperative myocardial infarction and was detected sooner than cardiac troponin I.6 However, another large trial showed that hFABP did not aid in the diagnosis of non-ST elevated myocardial infarctions over cardiac troponin.7
Comparison between creatine kinase MB, heart-type fatty acid-binding protein, and cardiac troponin T for detecting myocardial ischemic injury after cardiac surgery
2019, Clinica Chimica ActaCitation Excerpt :The study of Malik et al. also showed that Heart-type fatty-acid–binding protein was a more rapid marker of perioperative myocardial damage than CK-MB in the patients with CABG [31]. The study of Thielmann et al. also told that H-FABP was a sensitive and rapid biomarker that detected MI reliably at 1 h after CABG, much earlier than cTnI [38]. MI is common after CABG [39].
Variables Affecting the Heart-Type Fatty Acid Binding Protein Level
2018, Annals of Thoracic SurgeryIncidence and Severity of Acute Myocardial Injury after Thoracic Surgery: Effects of Nicorandil
2023, Rational Pharmacotherapy in Cardiology