Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1812, Issue 8, August 2011, Pages 956-963
ReviewNuclear receptor PXR, transcriptional circuits and metabolic relevance☆,☆☆
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Research highlights
► PXR was initially cloned as a xenobiotic receptor regulating drug metabolism. ► Accumulating evidence has suggested broader transcriptional circuits controlled by this receptor. ► Moreover, the perceived function of PXR has been extended to a sensor that dictates the homeostasis of both xenobiotics and endobiotics.
Abbreviations
CYP
cytochrome P450
DDI
drug–drug interaction
G6Pase
glucose-6-phosphatase
GST
glutathione S-transferase
NR
nuclear receptor
PCN
prenenolone-16α-carbonitrile
PEPCK
phosphoenolpyruvate carboxykinase
PXR
pregnane X receptor
RIF
rifampicin
SULT
sulfotransferase
UGT
UDP-glucuronosyl transferase
XRE
xenobiotic response element
Keywords
Nuclear receptor
Gene regulation
Xenobiotic receptor
Xenobiotics
Endobiotics
Cited by (0)
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- ☆☆
This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease.
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