Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1813, Issue 4, April 2011, Pages 540-545
ReviewMitochondrial outer membrane permeabilization during apoptosis: The role of mitochondrial fission☆
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Research highlights
► Mitochondria continually fuse and divide. ► As a result, they form a dynamic network of interconnected organelles. ► Collapse of this network is observed early during apoptosis. ► We address the mechanisms underlying the mitochondrial fragmentation. ► We review how it contributes to cell death.
Abbreviations
MOMP
mitochondrial outer membrane permeabilization
MIM
mitochondrial inner membrane
MOM
mitochondrial outer membrane
IMS
intermembrane space
BH3
Bcl-2 homology domain 3
MEFs
mouse embryonic fibroblasts
Keywords
Mitochondria
Apoptosis
Fission
Fusion
Bax
Drp1
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This article is part of a Special Issue entitled Mitochondria: the deadly organelle.
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