Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1833, Issue 4, April 2013, Pages 901-908
ReviewA-kinase anchoring proteins: Molecular regulators of the cardiac stress response☆
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Highlights
► A-kinase anchoring proteins (AKAPs) assemble multienzyme signaling complexes in cells. ► AKAPs coordinate signaling cascades that regulate the cardiac response to stress. ► We analyze recent literature describing the role of AKAPs in cardiac pathophysiology. ► We discuss the role of AKAPs in the hypoxic heart and in cardiac remodeling.
Keywords
A kinase anchoring protein (AKAP)
Protein kinase A
Cardiac remodeling
Signaling
Cardiomyocyte
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This article is part of a Special Issue entitled: Cardiomyocyte Biology: Cardiac Pathways of Differentiation, Metabolism and Contraction.
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