ReviewNormal and abnormal functions of adenosine receptors in the central nervous system revealed by genetic knockout studies☆
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Research Highlights
► ARs integrate and fine-tune multiple neurotransmitters and CNS signaling pathways. ► Striatal A2AR activity is critical for habit learning and cognitive control. ► AR-effects depend on the local brain pathology and timing of intervention. ► A2ARs represent important targets for neuropsychiatric diseases. ► AR-based drugs may need to be tailored to the specific disease process.
Keywords
Adenosine
Adenosine receptors
A1 receptor, A2A receptor, knockout
Neuroprotection
Cognition
Neuroinflammation
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This article is part of a Special Issue entitled: “Adenosine Receptors”.
Copyright © 2010 Published by Elsevier B.V.