Review
The α2δ subunits of voltage-gated calcium channels

https://doi.org/10.1016/j.bbamem.2012.11.019Get rights and content
Under a Creative Commons license
open access

Abstract

Voltage-gated calcium channels consist of the main pore-forming α1 subunit, together, except in the case of the T-type channels, with β and α2δ and sometimes γ subunits, which are collectively termed auxiliary or accessory subunits. This review will concentrate on the properties and role of the α2δ subunits of these channels. These proteins are largely extracellular, membrane-associated proteins which influence the trafficking, localization, and biophysical properties of the channels. This article is part of a Special Issue entitled: Calcium channels.

Graphical abstract

Highlights

► This review discusses the α2δ subunits of voltage-gated calcium channels. ► The α2δ subunits are involved in calcium channel trafficking. ► The α2δ subunits also affect biophysical properties of calcium channel currents. ► The α2δ subunits are associated with several different pathologies.

Abbreviations

DHP
dihydropyridine
DRG
dorsal root ganglion
ER
endoplasmic reticulum
HVA
high-voltage activated
LVA
low voltage-activated
MIDAS
metal ion dependent adhesion site
VWA
von Willebrand factor-A

Keywords

Calcium channel
Auxiliary subunit
Electrophysiology
Alpha2delta

Cited by (0)

This article is part of a Special Issue entitled: Calcium channels.