Brief reportNormal Brain Tissue Volumes after Long-Term Recovery in Anorexia and Bulimia Nervosa
Section snippets
Sample Collection
Forty recovered ED subjects were recruited, 14 meeting criteria for restricting type AN (RAN), 16 for binge-purging type AN (BAN) and 10 for BN. To be considered “recovered,” for the previous year subjects had to (1) maintain a weight above 85% of average body weight; (2) have regular menstrual cycles; (3) have not binged, purged, restricted food intake or exercised excessively; and (4) not used psychoactive medications. Thirty-one CW were recruited. They had no history of an ED or any
Results
Recovered subjects and CW were of similar age and body mass index (BMI) (Table 1). The average length of recovery ranged from 29.8 to 39.5 months. Groups had similar volumes for total (Table 2) GM, WM, and CSF as well as regional values (data not shown). There was a small but not significant decline of total GMV with age, while total WMV and total CSF volume showed a small but not significant increase in all recovered subjects (age/GMV: r = −.193, p = .232; age/ WMV: r = .167, p = .304; age vs.
References (25)
- et al.
Reversibility of cerebral ventricular enlargement in anorexia nervosa, demonstrated by quantitative magnetic resonance imaging
J Pediatr
(1996) - et al.
A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains
Neuroimage
(2001) - et al.
Automatic Differentiation of Anatomical Patterns in the Human BrainValidation with Studies of Degenerative Dementias
NeuroImage
(2002) - et al.
Cerebral atrophy in bulimia
Biol Psychiatry
(1989) - et al.
Subcortical Brain Anatomy in Anorexia and Bulimia
Biol Psychiatry
(1992) - et al.
Cerebral gray matter and white matter volume deficits in adolescent girls with anorexia nervosa
J Pediatri
(1996) - et al.
Structural brain abnormalities in patients with bulimia nervosa
Psychiatry Res
(1989) - et al.
Endocrine, metabolic, and cranial computed tomographic findings in AN
Biol Psychiatry
(1988) - Bailer UF, Frank GK, Henry SE, Price JC, Meltzer CC, Weissfeld L, et al (in Press): Altered brain serotonin 5-HT1A...
- et al.
Altered 5-HT2A receptor binding after recovery from bulimia-type anorexia nervosarelationships to harm avoidance and drive for thinness
Neuropsychopharmacology
(2004)
Structural brain changes in patients with anorexia nervosa
Psychol Medicine
Users guide for the structured clinical interview for DSM-IV Axis I disorders- research version
Cited by (137)
Dynamic Structural Brain Changes in Anorexia Nervosa: A Replication Study, Mega-analysis, and Virtual Histology Approach
2022, Journal of the American Academy of Child and Adolescent PsychiatryStriatal volumes as potential biomarkers in Eating Disorders: A pilot study
2022, Revista de Psiquiatria y Salud MentalMetacognition in individuals recovered from anorexia nervosa: a voxel-based morphometry study.
2020, Psychiatry Research - NeuroimagingCitation Excerpt :However, while adequate weight restoration and recovery seem to be crucial for global brain volumes normalization to occur, the findings on regional GMV are rather inconsistent. While some studies support the hypothesis of a full recovery of both global and local GMV after eating and weight normalization (Bang et al., 2016; Nickel et al., 2018; Wagner et al., 2006), other studies claim that regional changes still remain detectable in recovered patients (Friederich et al., 2012; Roberto et al., 2011). Consistently with this latter evidence, our VBM whole brain analysis revealed between-group differences in the left Inferior Frontal Gyrus (IFG): in more detail, decreased regional GMV within this region characterized the rec-AN group compared to HC.
Alterations of brain structure and functions in anorexia nervosa
2019, Clinical Nutrition Experimental