Archival ReportMeta-Analysis of Brain Volume Changes in Obsessive-Compulsive Disorder
Section snippets
Data Sources and Study Selection Process
We searched the MEDLINE and PsycINFO databases through March 2008, without limits on year of publication, using the Key words obsessive compulsive disorder and any of the following terms: imaging, neuroimaging, structural imaging, magnetic resonance imaging, or MRI. The reference lists of identified articles and review articles were also searched to obtain additional papers. Studies were considered for inclusion if 1) they were published in English in a peer-reviewed journal, 2) they used MRI,
Results
Among 21 MRI articles fulfilling our inclusion criteria, 15 investigations, from 14 articles, contributed to at least three assessments for a given cerebral region (Figure 1) (6, 7, 10, 11, 12, 13, 14, 15, 16, 18, 19, 23, 25, 28). These primary results and characteristics are summarized in Table 1. Included studies comprised a total of 371 OCD patients and 407 healthy control subjects. Study populations differed markedly in several demographic and clinical characteristics. The mean age ranged
Discussion
This meta-analysis provides a quantitative evaluation of volumetric alterations in OCD by integrating outcomes from 14 MRI case-control studies that included 371 patients and 407 healthy control subjects. Our results indicate the existence of a reliably smaller volume in both the ACC and OFC, as well as an increase of thalamic volume in OCD patients relative to healthy control subjects, suggesting that the thalamocortical pathway plays a primary role in OCD pathophysiology. Our findings show no
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