Archival ReportAuditory Hallucinations in Schizophrenia Are Associated with Reduced Functional Connectivity of the Temporo-Parietal Area
Section snippets
Subjects
The study was approved by the Institutional Review Board (University Medical Center Groningen). Twenty-seven patients, meeting DSM-IV criteria for schizophrenia—confirmed by a Schedules for Clinical Assessment in Neuropsychiatry (SCAN) interview (36)—and 27 healthy matched control subjects recruited via advertisement in the local community participated in the study. Detailed clinical and demographical data are presented in Table 1. Before participation, informed consent was obtained. All
Effects of Symptomatology
Analysis of group differences revealed a widespread decrease of functional connectivity with the TPJ in the patients, compared with control subjects. However, the only effect surviving FDR correction was a significantly decreased connectivity between left TPJ and the right homotope of Broca's area in patients compared with control subjects (Z = −2.88; p = .004; Figure 1).
Correlational analyses within the group of hallucinators revealed a negative association between the P3 hallucination item of
Discussion
This study aimed to relate AVH in patients with schizophrenia to patterns of functional connectivity during the resting state. The bilateral TPJ, a critical region in AVH genesis (37), was selected as a seed region; and its connection to other ROIs previously linked to AVH activity and speech perception processes was assessed.
Compared with healthy control subjects, patients showed reduced functional connectivity between the left TPJ and the right hemispheric homotope of Broca's area, which
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2023, NeuroImageCitation Excerpt :In line with previous studies, our findings strongly suggested distinct roles of the bilateral TPJ in the dual interaction between SON and HERs. As the left TPJ is also involved in language processing (Vercammen et al., 2010), SON, as a kind of linguistic stimulus, could modulate the HERs in the left TPJ. The right TPJ, on the other hand, has been proposed to be associated with self-other attribution (Eddy, 2016; Plaze et al., 2015; Ruby and Decety, 2001) and self-related judgments (Jeannerod, 2009).
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