Archival ReportDeep Brain Stimulation for Intractable Obsessive Compulsive Disorder: Pilot Study Using a Blinded, Staggered-Onset Design
Section snippets
Patients
This study was conducted at the University of Florida as a collaboration of the departments of Psychiatry, Neurology, and Neurosurgery in consultation with Dr. Benjamin Greenberg of Brown University. Prior to recommending surgery, an independent internal multidisciplinary team (psychiatrist, neurologist, neurosurgeon, and medical ethicist) reviewed all past treatments, evaluations, and procedures to ensure appropriateness of the candidate. Psychiatric diagnoses were based upon administration of
DBS Lead Locations and Programming
A summary of the active DBS contacts used for chronic stimulation is provided in Table 1 along with lead locations. Three patients (patients 2, 3, and 5) had sham DBS programming for 1 month and then were subsequently activated at the next study visit under double-blind conditions. All patients were activated in a single contact monopolar setting for the first 6 months. Following the 6-month time point, trials of multiple monopolar stimulation resulted in salvage of one patient (patient 3) but
Discussion
Twelve months of bilateral stimulation of the VC/VS was associated with marked improvement in obsessive compulsive symptoms in four (66.7%) of six subjects with severe and intractable OCD. Even the two individuals who were classified as nonresponders requested that stimulation be continued because they experienced some subjective relief of anxiety, depressive, or tic symptoms. For the six subjects as a whole, both OCD and depressive symptoms improved significantly compared with baseline at the
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