Archival ReportBrain Network Connectivity in Individuals with Schizophrenia and Their Siblings
Section snippets
Participants
The participants (Table 1) for this study were recruited through the Conte Center for the Neuroscience of Mental Disorders at Washington University School of Medicine in St. Louis and included: 1) probands who were individuals with DSM-IV schizophrenia (SCZ; n = 25); 2) the nonpsychotic siblings of individuals with schizophrenia (SCZ-SIB; n = 31); 3) healthy control subjects (CON; n = 15); and 4) the siblings of healthy control subjects (CON-SIB; n = 18). Siblings were full siblings, based on
Within-Network Connectivity
The within-network ANOVA included diagnostic group and sibling type as between-subject factors and network as a within-subject factor. This ANOVA revealed a trend level main effect of diagnostic group [F(1,85) = 3.34, p = .07], which reflected slightly lower within-network connectivity among SCZ and SCZ-SIB compared with CON and CON-SIB (Figure 2). We next examined whether specific regions within any of the networks showed reduced connectivity with its own network. To do so, we computed, for
Discussion
The goal of the current study was to examine differences in functional connectivity within and between known brain networks in patients with schizophrenia and their unaffected siblings to test the hypothesis that schizophrenia involves disruptions in the coordinated activity of brain regions. Our results suggest that both individuals with schizophrenia and their siblings have impaired brain connectivity and that these impairments are most prominent between networks compared with within
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