Research review paperDiscovery and resupply of pharmacologically active plant-derived natural products: A review
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Abbreviations
4CL
4-coumaroyl CoA ligase
ADME/T
absorption, distribution, metabolism, excretion (and toxicity)
BIA
benzylisoquinoline alkaloid
C4H
cinnamate 4-hydroxylase
CoA
coenzyme A
CRISPR/Cas9
clustered regulatory interspaced short palindromic repeat/CRISPR associated protein 9
DMPP
dimethylallyl-pyrophosphate
DNP
Dictionary of Natural Products
DNTI
Drugs from Nature Targeting Inflammation
EMA
European Medicines Agency
FDA
US Food and Drug Administration
GGPP
geranylgeranyl diphosphate
GPCR
G-protein coupled receptor
GC
gas chromatography
HPLC
high performance liquid chromatography
HTS
high-throughput screening
iNOS
inducible nitric oxide synthase
IPP
isopentenyl-pyrophosphate
MEP
2C-methyl-d-erythriol-4-phosphate
MS
mass spectrometry
NCI
(US) National Cancer Institute
NCT
National Clinical Trial
NME
new molecular entity
NMR
nuclear magnetic resonance
NPD
Natural Product Database
OPLS-DA
orthogonal projection to latent structures discriminant analysis
PAL
phenylalanine ammonia lyase
PLS-DA
partial least square regression modeling discriminant analysis
PPAR
peroxisome proliferator-activated receptor
QSAR
quantitative structure activity relationship
TAL
tyrosine ammonia lyase
TALEN
transcription activator-like effector nuclease
TCM
traditional Chinese medicine
THC
tetrahydrocannabinol
SHE
safety, health, and environment
Keywords
Natural products
Plants
Drug discovery
Phytochemistry
Pharmacology
Medicine
Ethnopharmacology
Computer modeling
Organic synthesis
Plant biotechnology
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These authors contributed equally to this work.
Copyright © 2015 The Authors. Published by Elsevier Inc.