Structure–activity relationships of ganoderma acids from Ganoderma lucidum as aldose reductase inhibitors
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Acknowledgements
We are thankful to Dr. Miyamoto for optical rotation measurement, to Mr. Matsumoto for HRESIMS measurement and Hitachi Scholarship Foundation - Japan, for postgraduate scholarship to S.F. The costs of publication were supported in part by the Research Grant for Young Investigators of Faculty of Agriculture, Kyushu University.
References and notes (32)
- et al.
Acta Pharmacol. Sin.
(2004) - et al.
Leuk. Res.
(2006) - et al.
Phytother. Res.
(2009) - et al.
Fitoterapia
(2010) - et al.
Chem. Pharm. Bull.
(2004) - et al.
Chem. Pharm. Bull.
(1985) - et al.
Mol. Vis.
(1998) - et al.
Curr. Sci.
(2002) - et al.
Jpn. J. Ophthalmol.
(1976)
Med. Res. Rev.
Expert Opin. Ther. Pat.
Planta Med.
Planta Med.
Planta Med.
Planta Med.
Planta Med.
Phytochemistry
Tetrahedron Lett.
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