Eudesmane-type sesquiterpene lactones inhibit multiple steps in the NF-κB signaling pathway induced by inflammatory cytokines
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Acknowledgment
This work was supported in part by a Grant-in-Aid for Scientific Research (KAKENHI) from Japan Society for the Promotion of Science (JSPS).
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2019, Discovery and Development of Anti-inflammatory Agents from Natural ProductsIsolation of eudesmanes from Pluchea odorata and evaluation of their effects on cancer cell growth and tumor invasiveness in vitro
2017, PhytochemistryCitation Excerpt :Several studies provide evidence for the effects of eudesmanes on various kinases and their specific and unspecific mode of action. As an example, it was shown that eudesmane-type sesquiterpenes can inhibit the release of the adhesion molecule ICAM-1, which is a prerequisite for CCID-formation (Kopf et al., 2013; Viola et al., 2013a), by suppressing multiple steps in the NF-κB pathway such as the IκB kinase (Chun et al., 2012; Li et al., 2014; Tamura et al., 2012). Furthermore, eudesmanes inhibit metastasis through NF-κB and phosphatidylinositide 3-kinase related pathways and subsequent regulation of urokinase-type plasminogen activator and diverse matrix metalloproteinases (Nakabayashi and Shimizu, 2012; Shi et al., 2014; Weidle et al., 2015).
Sesquiterpene Lactones: Structural Diversity and Perspectives as Anti-Inflammatory Molecules
2016, Studies in Natural Products ChemistryCitation Excerpt :IκBα degradation can be blocked by α,β-unsaturated carbonyl moieties of α-methylene-γ-lactones, which react with thiol groups of critical cysteine (Cys-179) in the IKK by Michael-type addition [90,91]. On the other hand, the prevention of nuclear translocation or DNA-binding of NF-κB occurs by alkylation of the critical cysteine residues (Cys38) in the DNA-binding domain of the p65 subunit of NF-κB [91,92]. Atractylenolide III (1), artemisinin (2), costunolide (3), and parthenolide (4) are some examples of SLs that can modulate inflammation by targeting NF-κB activation.
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