Cancer Letters

Cancer Letters

Volume 254, Issue 2, 8 September 2007, Pages 178-216
Cancer Letters

Mini-review
Oncolytic viruses in cancer therapy

https://doi.org/10.1016/j.canlet.2007.02.002Get rights and content

Abstract

Oncolytic virotherapy is a promising form of gene therapy for cancer, employing nature’s own agents to find and destroy malignant cells. The purpose of this review is to provide an introduction to this very topical field of research and to point out some of the current observations, insights and ideas circulating in the literature. We have strived to acknowledge as many different oncolytic viruses as possible to give a broader picture of targeting cancer using viruses. Some of the newest additions to the panel of oncolytic viruses include the avian adenovirus, foamy virus, myxoma virus, yaba-like disease virus, echovirus type 1, bovine herpesvirus 4, Saimiri virus, feline panleukopenia virus, Sendai virus and the non-human coronaviruses. Although promising, virotherapy still faces many obstacles that need to be addressed, including the emergence of virus-resistant tumor cells.

Abbreviations

CNS
central nervous system
ECM
extracellular matrix
HIV
human immunodeficiency virus
HSV
herpes simplex type 1 virus
IFN
interferon
MOI
multiplicity of infection
(Mo)MLV
(Moloney) murine leukemia virus
NDV
Newcastle disease virus
PKR
protein kinase R
PFU
plaque-forming unit
SFV
Semliki Forest virus
VSV
vesicular stomatitis virus
VV
Vaccinia virus
VLP
viral-like particle
TK
thymidine kinase
i.v.
intravenous
i.t.
intratumoral
i.p.
intraperitoneal
i.c.
intracranial
WT
wildtype
TAA
tumor associated antigen
FMG
fusogenic membrane glycoprotein

Keywords

Cancer gene therapy
Oncolytic
Replication-competent
Replication-deficient
Virotherapy
Virus-resistant

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