Cancer Cell
Volume 31, Issue 1, 9 January 2017, Pages 5-19
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Review
Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer

https://doi.org/10.1016/j.ccell.2016.12.006Get rights and content
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Pancreatic ductal adenocarcinoma is on pace to become the second leading cause of cancer-related death. The high mortality rate results from a lack of methods for early detection and the inability to successfully treat patients once diagnosed. Pancreatic cancer cells have extensively reprogrammed metabolism, which is driven by oncogene-mediated cell-autonomous pathways, the unique physiology of the tumor microenvironment, and interactions with non-cancer cells. In this review, we discuss how recent efforts delineating rewired metabolic networks in pancreatic cancer have revealed new in-roads to develop detection and treatment strategies for this dreadful disease.

Keywords

pancreatic cancer
PDAC
tumor metabolism
metabolic imaging
metabolic reprogramming
stroma
Kras
metabolic crosstalk
HP-MRI
FDG-PET

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