Cancer Cell
Volume 6, Issue 3, September 2004, Pages 203-208
Journal home page for Cancer Cell

Minireview
Nuclear factor-κB: The enemy within

https://doi.org/10.1016/j.ccr.2004.09.003Get rights and content
Under an Elsevier user license
open archive

Abstract

Numerous lines of investigation suggest that nuclear factor NF-κB, a proinflammatory transcription factor, could promote tumorigenesis. Various inflammatory agents, carcinogens, tumor promoters, and the tumor microenvironment activate NF-κB. NF-κB proteins themselves and proteins regulated by it have been linked to cellular transformation, proliferation, apoptosis suppression, invasion, angiogenesis, and metastasis. Constitutively activated NF-κB is common in wide variety of tumors. Furthermore, there exists genetic evidence that NF-κB mediates tumorigenesis. Thus, suppression of NF-κB activation should be effective in the prevention and treatment of cancer.

Cited by (0)