Cancer Cell
Volume 17, Issue 2, 17 February 2010, Pages 135-147
ArticleCancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner
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Graphical Abstract
Highlights
► Carcinoma-associated fibroblasts (CAFs) mediate proangiogenic inflammation ► CAFs in skin, breast, and pancreatic tumors express proinflammatory genes ► Tumor-enhancing activity of skin CAFs is NF-κB dependent and activatable by IL-1β ► Dermal fibroblasts can be educated by cancer cells to become pro-inflammatory CAFs
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Present address: Swiss Institute for Experimental Cancer Research, Swiss Federal Institute of Technology Lausanne, Lausanne CH-1015, Switzerland
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