Cancer Cell
Volume 19, Issue 2, 15 February 2011, Pages 244-256
ArticleA Functional Role for Tumor Cell Heterogeneity in a Mouse Model of Small Cell Lung Cancer
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Highlights
► SCLC tumors are often composed of neuroendocrine (NE) and mesenchymal (NonNE) cells ► The NE and NonNE tumor cell lineages are often derived from a common progenitor ► RasV12 can command the transition from the NE to a NonNE phenotype ► NonNE cells endow NE cells with metastatic capacity through paracrine signaling
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These authors contributed equally to this work
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Present address: Metabolic Engineering and Diabetes Therapy Lab., Institute for Research in Biomedicine (IRB Barcelona), 08028 Barcelona, Spain
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Present address: Centre Recherche INSERM U823 Equipe 2, Institut Albert Bonniot 38706 La Tronche Cedex, Grenoble, France
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