Cell
Volume 147, Issue 1, 30 September 2011, Pages 235-246
ArticleAbsence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related Deficits
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Graphical Abstract
Highlights
► The Cntnap2−/− mouse model of ASD shows striking parallels with the human disease ► CNTNAP2 affects the development of neuronal circuits, including GABAergic neurons ► Our results support a role for neuronal synchrony in the pathophysiology of ASD ► This model permits dissociation of the circuitries involved in ASD core behaviors
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Present address: Departments of Genetics and Neuroscience, Price Center for Genetic and Translational Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
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Present address: Yale MSTP Program, Yale School of Medicine, New Haven, CT 06511, USA
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