Lck/PLCγ control migration and proliferation of interleukin (IL)-2-stimulated T cells via the Rac1 GTPase/glycogen phosphorylase pathway
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Abbreviations
PYGM
glycogen phosphorylase muscle isoform
Lck
lymphocyte-specific protein tyrosine kinase
PLCγ
phospholipase
PI3K
phosphatidylinositide 3-kinase
AKs
Janus kinases
STAT
signal transducer and activator of transcription
GEF
Guanine Nucleotide Exchange Factor
IL-2
Interleukin 2
IL-2-R
Interleukin 2 receptor
RBD
Rac binding domain
TCR
T cell receptor
BCR
B cell receptor
DMSO
dimethyl sulfoxide
Keywords
Cell migration and proliferation
Glycogen phosphorylase
Lck
Plc
Phosphoserine
Phosphotyrosine
Rac1
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© 2016 The Authors. Published by Elsevier Inc.