Endoscopy cornerClinical Evaluation of Endoscopic Trimodal Imaging for the Detection and Differentiation of Colonic Polyps
Section snippets
Patients
Patients scheduled for colonoscopy in the Academic Medical Center in Amsterdam were screened for participation. Inclusion criteria were a personal history of adenomas or CRC, or a positive family history for CRC (one first-degree family member fulfilling one of the revised Bethesda criteria).38 Exclusion criteria were age younger than 18 years, polyposis syndromes, inflammatory bowel disease, severe coagulopathy, and insufficient bowel preparation. Eligible patients were invited for this study
Patient Characteristics
Between June 2005 and March 2007 a total of 109 patients gave informed consent; 6 patients were excluded because of poor bowel preparation and 3 patients were excluded because of a technically difficult and painful colonoscopy (Figure 3). The mean age of the remaining 100 patients (43 male) was 52 years (±14 y) and the cecal intubation rate was 100%. Fifty patients underwent tandem colonoscopy with a first inspection in the AFI mode; the remaining 50 patients were examined with HRE first. No
Discussion
Because adenoma miss-rates may cause interval cancers in patients undergoing periodic colonoscopy, great efforts are being made to reduce miss-rates by good quality colonoscopy and advanced imaging techniques.8 Chromoendoscopy has been shown to improve both the detection and differentiation of colonic polyps.15, 16, 17, 18, 19, 20 However, advanced imaging techniques such as AFI and NBI are easier to use and may be more cost effective because they involve only a push on a button instead of the
Acknowledgements
Trial registration is as follows: Trialregister.nl, identifier: ISRCTN76121851.
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Cited by (0)
Conflicts of interest The authors disclose the following: Dr van den Broek is supported by an unrestricted educational grant from Olympus Inc (Hamburg, Germany); Dr Fockens has received a research grant from Olympus Inc (Tokyo, Japan); and the Department of Gastroenterology at the Academic Medical Center was provided with loan endoscopic equipment by Olympus Inc. No disclosures were made to study participants.