Original articles—alimentary tractNo Association Between Gastric Fundic Gland Polyps and Gastrointestinal Neoplasia in a Study of Over 100,000 Patients
Section snippets
Study Setting
This study was conducted at Caris Diagnostics, a specialized gastrointestinal laboratory receiving specimens from gastroenterologists operating in outpatient endoscopy centers in 36 states, Puerto Rico, and the District of Columbia. Biopsies are interpreted by an experienced group of gastrointestinal pathologists who share a common approach to biopsy evaluation and maintain a relative uniformity through internally standardized specimen handling, diagnostic criteria, and terminology.
Prevalence of FGPs
The database contained 121,564 unique patient encounters which included an EGD with biopsies; after excluding patients whose biopsies had not been diagnosed at the Caris Diagnostics Irving laboratory, those who had cytologic specimens only, and external consults, there remained a total of 103,385 unique patients (61,007 women, or 59.0%). Of these, 78,801 patients had one or more gastric biopsies, whereas the remaining 24,584 patients had biopsies from the esophagus or the duodenum, but not from
Discussion
The prevalence of FGPs has been reported to lie between 0.21% (in Italy)19 and 2.0% (in Northern Ireland).10 In the Irish study Dickey et al showed considerable foresight by commenting that “it is too early to say that their prevalence will increase as H pylori incidence falls and proton pump inhibitor use grows, but improving endoscopic resolution will be sufficient in itself to bring their attention to the endoscopist more often.” Twelve years later, in our study of almost 80,000 patients who
References (24)
- et al.
Gastric lesions in familial adenomatosis coli: their incidence and histologic analysis
Hum Pathol
(1978) - et al.
Long-term omeprazole treatment and fundic gland polyps: a very authoritative proof against a link?
Am J Gastroenterol
(2001) - et al.
Fundic gland polyps (Elster's cysts) of the gastric mucosaA marker for colorectal epithelial neoplasia?
Pathol Res Pract
(2002) - et al.
Sporadic fundic gland polyps: an immunohistochemical study of their antigenic profile
Pathol Res Pract
(1996) Differential diagnosis of reactive gastropathy
Semin Diagn Pathol
(2005)- et al.
Proton pump inhibitor use and risk of colorectal cancer: a population-based, case-control study
Gastroenterology
(2007) - et al.
A closer look at same-day bidirectional endoscopy
Gastrointest Endosc
(2009) - et al.
Gastric lesion of familial polyposis coli
Cancer
(1974) - et al.
The glandular cyst, a polypoid lesion of the gastric mucosa
Dtsch Med Wochenschr
(1977) - et al.
Fundic gland polyps are not induced by proton pump inhibitor therapy
Am J Clin Pathol
(2001)
Fundic gland polyps developing during omeprazole therapy
Am J Gastroenterol
Proton pump inhibitor-associated gastric polyps: a retrospective analysis of their frequency, and endoscopic, histologic, and ultrastructural characteristics
Am J Clin Pathol
Cited by (0)
Conflicts of interest The authors disclose no conflicts.