Original articleAlimentary tractPrevalence of and Risk Factors for Colorectal Neoplasia in Asymptomatic Young Adults (20–39 Years Old)
Section snippets
Study Population
The Kangbuk Samsung Health Study is a cohort study of South Korean men and women aged ≥18 years who underwent a comprehensive annual or biennial health examination at the Kangbuk Samsung Hospital Total Healthcare Center in Seoul and Suwon, South Korea. The study population consisted of a subset of Kangbuk Samsung Health Study participants aged 20–39 years who underwent colonoscopy as part of a health check-up from August 2004 to December 2015 (n = 94,805). We retrospectively analyzed data
Baseline Characteristics of the Study Population
We reviewed the medical records of 94,805 participants aged 20–39 years who underwent colonoscopy. Of them, 22,449 were excluded because of a prior colonic examination, colorectal surgery, or CRN (n = 11,995); history of inflammatory bowel disease (n = 197); family history of CRC (n = 2345); and poor bowel preparation (n = 7912). Ultimately, 72,356 participants were analyzed. The mean age of the study participants was 34.0 ± 3.4 years, and the proportion of male patients was 68.6%.
Of the 72,356
Discussion
In this very large study of an asymptomatic young population, we found that CRN in subjects aged 20–29 years and those 30–39 years was 5.9% and 9.5%, respectively. In subjects aged 20–29 years, obesity, abdominal obesity, and elevated triglyceride were independent risk factors for both overall and advanced CRN, while age, elevated blood pressure, and elevated FBG were also independent risk factors for overall CRN. In subjects aged 30–39 years, age, smoking, alcohol intake, obesity, and
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Conflicts of interest The authors disclose no conflicts.
Funding This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (Ministry of Science and ICT) (NRF-2017R1A2B4004988).