Aspirin for the Prevention of Preeclampsia and Intrauterine Growth Restriction

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Key points

  • Low-dose aspirin (LDA) (80–160 mg) reduces the risk of preeclampsia (PE) and intrauterine growth restriction by approximately half when started in early pregnancy.

  • LDA reduces mainly the preterm and severe forms of PE when started in early pregnancy.

  • Women with chronic hypertension and those with prior PE should begin taking LDA in early pregnancy.

  • First-trimester screening programs should be implemented to identify women at high-risk for preterm or severe PE.

  • Further studies should evaluate the

Summary

Studies have demonstrated that LDA administered in early gestation is efficient in reducing the risk of PE, IUGR, preterm birth, and perinatal death in high-risk women, especially those at high risk for deep placentation disorders, preterm PE, and severe IUGR. First-trimester screening programs for such adverse pregnancy outcomes are increasingly promising, and recent studies combining a first-trimester screening strategy with prophylactic LDA demonstrated a significant decrease of early onset

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    Disclosure: None of the authors have a conflict of interest.

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