Cell Metabolism
Volume 26, Issue 6, 5 December 2017, Pages 809-811
Journal home page for Cell Metabolism

Preview
Transcriptional Noise and Somatic Mutations in the Aging Pancreas

https://doi.org/10.1016/j.cmet.2017.11.009Get rights and content
Under an Elsevier user license
open archive

The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations.

Cited by (0)