Biomaterials-based in situ tissue engineering

doi:10.1016/j.cobme.2017.01.001

Current Opinion in Biomedical Engineering

Volume 1, March 2017, Pages 4-7

https://doi.org/10.1016/j.cobme.2017.01.001 Get rights and content

Highlights

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In situ tissue engineering uses the body as a bioreactor.
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Biomaterials with or without cells are suitable for in situ tissue engineering.
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Suitable biomaterials must be degradable and not pro inflammatory.
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In situ tissue engineering utilizes endogenous cells for tissue reconstruction.

Graphical abstract

Section snippets

Biomaterials for in situ tissue engineering

Materials suitable for in situ tissue engineering (TE) include those that are either synthetic or naturally occurring in composition. However, such materials must possess the following two properties: be degradable, and elicit either a minimal pro-inflammatory response or an anti-inflammatory, immunomodulatory response. The formation of new, site-appropriate tissue that at least partially restores structure and function to the injured or missing anatomy implies circumvention of the default

Synthetic biomaterials

Synthetic biomaterials are commonly used in the practice of medicine and are manufactured from a variety of base materials such as stainless steel, polypropylene, silicone, and polyurethanes, among others 1, 2, 3, 4. Synthetic biomaterials can be manufactured with high precision and can be terminally sterilized and packaged by well-recognized and accepted methods. Some synthetic materials are degradable within the human body (e.g., polylactic-glycolic acid) while others are essentially

Naturally occurring materials

Materials composed of the secreted products of cells, including the extracellular matrix (ECM) or individual components of ECM such as collagen, are considered to be naturally occurring materials. For example, ECM bioscaffold materials composed of urinary bladder matrix (UBM) and small intestinal submucosa (SIS) are manufactured by the decellularization of their source tissue. These materials often retain sufficient bioactivity to promote positive remodeling effects such as

Hybrid biomaterial approaches

To capitalize upon the positive features of both synthetic and biologic materials, hybrids have been used for in situ use. For example, the strength and architectural versatility of synthetic scaffolds can be combined with the bioactive signals and biocompatibility of natural scaffold materials. Photo-crosslinkable methacrylated chondroitin sulphate and adipose-derived stem cells were used with or without decellularized adipose tissue in hydrogel form as a minimally invasive in situ approach to

Conclusion

Limitations in the understanding of biologic events that are required for normal tissue in organ development hinder the successful clinical translation of tissue engineering approaches that require extensive ex vivo bioreactor time. By using the body as a bioreactor, one can capitalize upon the natural in vivo microenvironment as an alternative TE approach; i.e., in situ TE. Biomaterials that can provide a favorable microenvironment for in situ TE include synthetic, biologic and hybrid

Acknowledgements

Mark Murdock is supported by the National Institutes of Health (NIH) Clinical and Translational Science (CTS) Fellowship program [grant number 1 TL1 TR 1858-1]. This CTS TL1 award had no role in the writing of this review or the decision to submit the article for publication.

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Biomaterials-based in situ tissue engineering

Highlights

Graphical abstract

Section snippets

Biomaterials for in situ tissue engineering

Synthetic biomaterials

Naturally occurring materials

Hybrid biomaterial approaches

Conclusion

Acknowledgements

First page preview

Mater. Lett.

J. Pediatr. Surg.

Br. J. Oral Maxillofac. Surg.

Rsc Adv.

Preparation and microstructure of HA-316L stainless steel fibre asymmetrical functionally graded biomaterial

J. Inorg. Mater.

Springy polypropylene – novel elastomeric biomaterial

Int. J. Polym. Mater.

A facile approach to modify polyurethane surfaces for biomaterial applications

Macromol. Biosci.

In situ tissue engineering of functional small-diameter blood vessels by host circulating cells only

Tissue Eng. Part A

Transplantation of chondrocytes utilizing a polymer-cell construct to produce tissue-engineered cartilage in the shape of a human ear

Plast. Reconstr. Surg.

Generating ears from cultured autologous auricular chondrocytes by using two-stage implantation in treatment of microtia

Plast. Reconstr. Surg.

A composite tissue-engineered trachea using sheep nasal chondrocyte and epithelial cells

Faseb J.

Tissue engineered cartilage generated from human trachea using DegraPol (R) scaffold

Eur. J. Cardiothorac. Surg.