CD40 −1C>T single nucleotide polymorphism and CD40 expression on breast tumors

doi:10.1016/j.cyto.2010.03.010

Cytokine

Volume 50, Issue 3, June 2010, Pages 243-244

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Cited by (7)

Single nucleotide polymorphism of CD40 in the 5'-untranslated region is associated with ischemic stroke
2013, Gene
Citation Excerpt :
Functional studies had shown that individuals who carried T genotypes or allele T of CD40 -1C/T have lower circulating sCD40 levels and reduced levels of CD40 on the surfaces of monocyte-derived activated dendritic cells and B cells (Jacobson et al., 2005; Skibola et al., 2008). It was probable that the allele T of CD40 -1C/T might reduce CD40 expression on neuronal cells, vascular endothelial cells, astrocytes and microglia in the CNS, inflammatory cells, as well as immune cell surfaces by hindering the stabilization of the mRNA-ribosome complex and inducing aberrant splicing, which could impede the immune system from mounting appropriate humoral and cell-mediated responses, and eliminate infectious agents (Dolen et al., 2010; Skibola et al., 2008). A low CD40 expression in these cells could reduce their half life and thus affect the pathophysiology pathway of ischemic stroke.
Ischemic stroke is influenced by both environmental and genetic factors. The CD40/CD40L system is related to proinflammatory and prothrombogenic responses, which are involved in the pathophysiology of ischemic stroke. The aim of this study was to evaluate association between the CD40 -1C/T single nucleotide polymorphism (SNP) and ischemic stroke in a Chinese population.
We conducted a case–control study including 286 ischemic stroke patients and 336 controls. CD40 -1C/T SNP was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing methods, and evaluated its relevance to ischemic stroke susceptibility.
Significantly increased ischemic stroke risk was found to be associated with the T allele of CD40 -1C/T (OR = 1.273, 95% CI = 1.016–1.594). The frequencies of CT and TT/CT genotypes of CD40 -1C/T in ischemic stroke patients were significantly higher than those of controls, respectively (for CT: OR = 2.350, 95% CI = 1.601–3.449; for TT/CT: OR = 2.148, 95% CI = 1.479–3.119). And, similar results were obtained after adjusting non-matched variables. We found that the frequency of carried T genotypes (TT and TT/CT) was significantly increased in patients with history of stroke compared with patients without (for TT: OR = 6.538, 95%CI = 1.655–25.833; for TT/CT: OR = 3.469, 95%CI = 1.031–11.670), respectively.
The findings suggested that the CD40 -1C/T polymorphism might contribute to the susceptibility to ischemic stroke in the Chinese population, and might be associated with history of previous stroke.
Relationship between polymorphisms in the CD40 gene with the prevalence of breast cancer: A case-control study
2023, Medical Journal of Tabriz University of Medical Sciences
CD40 polymorphism in cervical carcinoma in a subset of Malaysian population
2017, Journal of Obstetrics and Gynaecology Research
Single nucleotide polymorphisms in the CD40 gene associate with the disease susceptibility and severity in knee osteoarthritis in the Chinese Han population: a case-control study
2017, BMC Musculoskeletal Disorders
Regulation of CD40 signaling in colon cancer cells and its implications in clinical tissues
2016, Cancer Immunology, Immunotherapy
CD40 and tolerance induction
2012, Iranian Journal of Allergy, Asthma and Immunology

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¹: Present address: Department of Medical Oncology, Bayindir Hospital, Ankara, Turkey.

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LetterCD40 −1C>T single nucleotide polymorphism and CD40 expression on breast tumors

Immunol. Today

Semin. Immunol.

Blood

Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth

Oncogene

Functional relevance of CD40 expression in human epidermis

Cell Biol. Toxicol.

CD40–CD40 ligand

J. Leukoc. Biol.

A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression

Genes Immun.

Letter
CD40 −1C>T single nucleotide polymorphism and CD40 expression on breast tumors