Elsevier

Diabetes & Metabolism

Volume 35, Issue 5, November 2009, Pages 422-424
Diabetes & Metabolism

Short Report
Profound weight loss in a type 2 diabetic patient with diabetic neuropathic cachexia: A case reportAmaigrissement majeur chez un diabétique de type 2 atteint de neuropathie cachectisante. Une observation

https://doi.org/10.1016/j.diabet.2009.06.001Get rights and content

Abstract

A 35-year-old morbidly obese man, diagnosed with type 2 diabetes in 2006, lost nearly 100 kg extremely rapidly soon after the diagnosis, with dramatic painful paraesthesia and autonomic neuropathy, and poor diabetes control. Investigations to find a tumour, or an infectious, endocrinological or digestive disease, to explain his clinical features were all negative. However, with insulin and analgesic treatment, the patient's symptoms improved markedly within a few months; the patient gained 50 kg, while insulin was tapered and then withdrawn, to be replaced by metformin, which maintained perfect diabetes control. Also, the analgesic therapies could be discontinued. This case report is typical of diabetic neuropathic cachexia, first described by Ellenberg in 1974.

Résumé

Le diagnostic de diabète de type 2 a été porté en 2006 chez un homme de 35 ans atteint d’obésité morbide. Très rapidement après le diagnostic du diabète, le patient perdit près de 100 kg, des douleurs intenses, des paresthésies diffuses et une neuropathie autonome apparurent parallèlement à un déséquilibre sévère du diabète. La recherche d’un cancer, d’une maladie infectieuse, endocrine ou digestive resta négative. Le traitement par insuline et antalgiques entraîna une disparition des symptômes cliniques en quelques mois, et le patient reprit 50 kg. L’insulinothérapie put être progressivement remplacée par un traitement par metformine et les antalgiques arrêtés. Ce cas clinique illustre la neuropathie diabétique cachectisante dont le premier cas a été décrit par Ellenberg en 1974 .

Introduction

Diabetic neuropathic cachexia (DNC), a rare form of peripheral neuropathy associated with impressive weight loss, was first described more than three decades ago by Ellenberg [1]. We report here on a typical case of DNC recently observed in Kuwait.

Section snippets

Case report

A 35-year-old morbidly obese man was diagnosed with type 2 diabetes in 2006. At the time of diagnosis, his weight was 170 kg and his height was 1.83 m (Fig. 1). Soon after the diagnosis, he was prescribed oral antidiabetic drugs by his GP.

Over the following year, the patient lost weight extremely rapidly and unintentionally. He had decreased appetite and poor diabetes control. When his HbA1c level reached 11.9%, the patient was referred to the diabetes unit for hyperosmolar hyperglycaemic

Discussion

Profound weight loss associated with dramatic painful paraesthesia and autonomic neuropathy arising soon after a diagnosis of type 2 diabetes, with no other microvascular diabetes-related complications and with total reversibility of all symptoms in one year, is typical of a diagnosis of DNC. DNC is predominantly seen in male patients with type 2 diabetes in their sixth decade and usually with no other specific complication of diabetes [1]. However, on rare occasions, cases have been reported

Conflicts of interest

None.

References (9)

  • M. Ellenberg

    Diabetic neuropathic cachexia

    Diabetes

    (1974)
  • N. Weintrob et al.

    Acute painful neuropathic cachexia in a young type I diabetic woman. A case report

    Diabetes Care

    (1997)
  • D.L. Wright et al.

    Diabetic neuropathic cachexia and hypothyroidism in a woman

    Mo Med

    (1987)
  • R.H. Blau

    Diabetic neuropathic cachexia. Report of a woman with this syndrome and review of the literature

    Arch Intern Med

    (1983)
There are more references available in the full text version of this article.

Cited by (8)

View all citing articles on Scopus
View full text