Elsevier

European Journal of Cancer

Volume 83, September 2017, Pages 103-105
European Journal of Cancer

Letter to the Editor
Colorectal cancer risk associated with the CHEK2 1100delC variant

https://doi.org/10.1016/j.ejca.2017.05.045Get rights and content

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Conflict of interest statement

None declared.

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    Highly penetrant cancer syndromes that increase risk of CRC include hereditary breast and ovarian cancer (associated with pathogenic variants in BRCA1, BRCA2, and PALB2 genes), Li-Fraumeni syndrome (caused by mutations in TP53), and familial atypical multiple melanoma (associated with pathogenic variants in CDKN2A).17,19,69–72 Cancer syndromes of moderate penetrance that are associated with breast cancer and increase risk of CRC are caused by variants in the ATM and CHEK2 genes.73–75 Studies are under way to quantify the risk of CRC related to these variants, and surveillance recommendations for CRC prevention are often modified.

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