Quantitative analysis of pulmonary artery and pulmonary collaterals in preoperative patients with pulmonary artery atresia using dual-source computed tomography☆
Section snippets
Patient population
Twenty PAA-VSD patients who had complete preoperative data of DSCT, echocardiography (ECHO) and CA were retrospectively analyzed in this study. Informed consent forms of DSCT and CA examinations were signed. In enrolled patients, there were 13 male and 7 female patients with age range from 43 days to 22 years old. In 20 patients, 10 patients were less than 5 years old (average height = 78.30 ± 16.90 cm; average weight = 9.53 ± 3.10 kg; body surface area = 0.45 ± 0.14 m2), 8 patients were 10–18 years old
Results
The final clinical diagnoses showed a total of 54 cardiac malformations in these 20 patients. As shown in Table 1, the echocardiography showed higher diagnostic rate of ASD than CTA and CA, but the difference was not statistically significant (χ2 = 1.06, p = 0.588). For overall cardiac malformations, the diagnostic rate was 94.4% (51/54) on DSCT, 85.2% on CA (p = 0.790 in comparison with DSCT), and 77.8% on echocardiography (p = 0.027 in comparison with DSCT), respectively.
The diagnostic rate of the
Discussion
Pulmonary artery atresia (PAA) with ventricular septal defect (VSD) is a rare congenital heart disease. The major pathological feature is no connection between right ventricle and pulmonary artery, and the pulmonary blood supply comes from systemic circulation. Ideally, earlier surgical repair will improve patient life quality and decrease death rate [1]. The electron beam CT and multi-slice spiral CT showed promising usefulness in depicting pre- and post-operative morphological changes in
Conflict of interest statement
None declared.
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The research was granted by the Youth Research Project of Fu Jian province, China (No. 2009-2-8).