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Treatment of aggression with topiramate in male borderline patients, part II: 18-month follow-up

Published online by Cambridge University Press:  16 April 2020

Marius K. Nickel  and
Thomas H. Loew
Marius K. Nickel*
Affiliation:
Clinic for Psychosomatic Medicine and Psychotherapy, Sommersbergseestrasse 395, Medical University of Graz, 8990Bad Aussee, Austria University Clinic for Psychiatry 1, PMU, Salzburg, Austria
Thomas H. Loew
Affiliation:
Department of Psychosomatic Medicine, University Clinic, Regensburg, Germany
*
*Corresponding author. Clinic for Psychosomatic Medicine and Psychotherapy, Sommersbergseestrasse 395, Medical University of Graz, 8990 Bad Aussee, Austria. Tel.: +43 3622 521003203. E-mail address: m.nickel@klinik-badaussee.at (M.K. Nickel).
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Abstract

Objective

We previously tested topiramate, an anticonvulsant, in the treatment of aggression in men with borderline personality disorder (BPD) (Nickel M, Nickel C, Kaplan P, Lahmann C, Mühlbacher M, Tritt K, et al. Treatment of aggression with topiramate in male borderline patients: a double-blind, placebo-controlled study. Biol Psychiatry 2005;57:495–9), and found significant changes on most scales of the state–trait anger expression inventory (STAXI) and significant weight loss eight weeks later. The aim of this trial was to assess topiramate's efficacy in the long-term therapy for aggression in men with BPD.

Methods

This 18-month follow-up observation, in which the previous patients (topiramate group: n = 22; former placebo group: n = 22) were examined bianually, was carried out.

Results

According to the intent-to-treat principle, significant changes on all scales of the STAXI were observed in the subjects treated with topiramate. Additional significant weight loss was observed. All subjects tolerated topiramate relatively well.

Conclusions

Topiramate appears to be an effective, relatively safe agent in the long-term treatment of patients with BPD. Mild, non-transient weight loss can be expected.

Keywords

Borderline personality disorderMen's healthAggressionTreatmentTopiramateWeight loss
Type
Short communication
Information
European Psychiatry , Volume 23 , Issue 2 , March 2008 , pp. 115 - 117
Copyright
Copyright © Elsevier Masson SAS 2008

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