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Temperament profiles, major depression, and response to treatment with SSRIs in psychiatric outpatients☆

Published online by Cambridge University Press:  15 April 2020

O. Kampman ,
O. Poutanen ,
A. Illi ,
E. Setälä-Soikkeli ,
M. Viikki ,
T. Nuolivirta  and
E. Leinonen
O. Kampman*
Affiliation:
University of Tampere, Medical School, 33014Tampere, Finland Seinäjoki Hospital District, Department of Psychiatry, Seinäjoki, Finland
O. Poutanen
Affiliation:
University of Tampere, Medical School, 33014Tampere, Finland Tampere University Hospital, Department of Psychiatry, 33014Tampere, Finland
A. Illi
Affiliation:
University of Tampere, Medical School, 33014Tampere, Finland
E. Setälä-Soikkeli
Affiliation:
Kanta-Häme Central Hospital, Department of Psychiatry, Hämeenlinna, Finland
M. Viikki
Affiliation:
University of Tampere, Medical School, 33014Tampere, Finland Tampere Mental Health Centre, Tampere, Finland
T. Nuolivirta
Affiliation:
Seinäjoki Hospital District, Department of Psychiatry, Seinäjoki, Finland
E. Leinonen
Affiliation:
University of Tampere, Medical School, 33014Tampere, Finland Tampere University Hospital, Department of Psychiatry, 33014Tampere, Finland
*
*Corresponding author.Tel.: +358 44 4155547(mobile); fax: +358 3 35516164. E-mail address: olli.kampman@uta.fi (O. Kampman).
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Abstract

Objective

The Temperament and Character Inventory (TCI) is commonly used in adult populations. Our aim was to explore: (1) if there are specific differences in temperament dimensions related to depression in comparison with general population, (2) if the treatment response during the acute phase of major depressive disorder (MDD) is predictable by TCI temperament dimensions.

Method

Temperament profiles in 98 MDD patients were compared with a Finnish community sample. The patients were treated with serotonin selective reuptake inhibitors (SSRIs) for 6weeks and their temperament profiles were assessed at baseline and endpoint. The harm avoidance (HA) and depression scores at baseline and endpoint were modelled with path analysis. For path modelling, we tested the relationships between different temperament dimensions and depression symptoms and other clinical variables with Mancova model.

Results

The HA scores were significantly higher in patients both at baseline and endpoint compared to the Northern Finland 1966 Birth Cohort (NFBC). The patients, and especially males, had slightly higher reward dependency (RD) scores. HA at endpoint explained moderately the Montgomery Åsberg Depression Rating Scale (MADRS) endpoint score. HA endpoint score was strongly explained by HA baseline score.

Conclusions

HA is associated with risk of and treatment response to depression.

Keywords

TemperamentInventoriesMajor depressionAntidepressive agentsSecond generationTherapeutic use
Type
Original article
Information
European Psychiatry , Volume 27 , Issue 4 , May 2012 , pp. 245 - 249
Copyright
Copyright © Elsevier Masson SAS 2012

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