Hostname: page-component-76fb5796d-vvkck Total loading time: 0 Render date: 2024-04-28T12:46:05.155Z Has data issue: false hasContentIssue false
  • English
  • Français

Repetitive Transcranial Magnetic Stimulation in Anorexia Nervosa: a Pilot Study

Published online by Cambridge University Press:  30 August 2011

F. Van den Eynde ,
S. Guillaume ,
H. Broadbent ,
I.C. Campbell  and
U. Schmidt
F. Van den Eynde*
Affiliation:
King's College London, Institute of Psychiatry, Section of Eating Disorders, De Crespigny Park, London, SE5 8AF, United Kingdom
S. Guillaume
Affiliation:
King's College London, Institute of Psychiatry, Section of Eating Disorders, De Crespigny Park, London, SE5 8AF, United Kingdom CHU de Montpellier, Université Montpellier I, Inserm U1061, Montpellier34006, France
H. Broadbent
Affiliation:
King's College London, Institute of Psychiatry, Section of Eating Disorders, De Crespigny Park, London, SE5 8AF, United Kingdom
I.C. Campbell
Affiliation:
King's College London, Institute of Psychiatry, Section of Eating Disorders, De Crespigny Park, London, SE5 8AF, United Kingdom
U. Schmidt
Affiliation:
King's College London, Institute of Psychiatry, Section of Eating Disorders, De Crespigny Park, London, SE5 8AF, United Kingdom
*
⁎Corresponding author. De Crespigny Park, Section of Eating Disorders PO Box 59, SE5 8AF London, United Kingdom. Tel.: +44 2078 480 160; fax: +44 2078 480 182. E-mail address: Frederique.van_den_eynde@kcl.ac.uk (F. Van den Eynde).
Get access

Abstract

The search for new treatments to improve outcome in people with anorexia nervosa continues. This pilot study investigated whether one session of high frequency repetitive transcranial magnetic stimulation (rTMS) delivered to the left dorsolateral prefrontal cortex reduces eating disorder related symptoms following exposure to visual and real food stimuli. Safety and tolerability were also assessed. Ten right-handed people with anorexia nervosa underwent one session of rTMS. Subjective experiences related to the eating disorder (e.g. urge to restrict, feeling full etc.) were assessed before and after rTMS. Non-parametric repeated measures tests were used. rTMS was safe and well-tolerated, and resulted in reduced levels of feeling full, feeling fat and feeling anxious. Thus, rTMS may reduce core symptoms of anorexia nervosa. Future research should establish the therapeutic potential of rTMS in anorexia nervosa.

Keywords

Anorexia nervosaRepetitive transcranial magnetic stimulationEating disordersDorsolateral prefrontal cortexInteroceptive awarenessCortisol concentrations
Type
Original article
Information
European Psychiatry , Volume 28 , Issue 2 , February 2013 , pp. 98 - 101
Copyright
Copyright © Elsevier Masson SAS 2013

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

1

FVDE and SG have equally contributed to the manuscript.

References

Baeken, C., De Raedt, R., Leyman, L., Schiettecatte, J., Kaufman, L., Poppe, K.et al.The impact of one HF rTMS session on mood and salivary cortisol in treatment-resistant unipolar melancholic depressed patients. J Affect Disord 2009;113:100–108.CrossRefGoogle ScholarPubMed
Berlim, M.T., McGirr, A., Beaulieu, M.M., Turecki, G.High frequency repetitive transcranial magnetic stimulation as an augmenting strategy in severe treatment-resistant major depression: A prospective 4-week naturalistic trial. J Affect Disord 2011. http://dx.doi.org/10.1016/j.jad.2010.10.011.CrossRefGoogle Scholar
Broadbent, H., Van den Eynde, F., Guillaume, S., Hanif, E.L., Stahl, D., David, A.et al.Blinding success of rTMS applied to the dorsolateral prefrontal cortex in randomised sham-controlled trials: a systematic review. World J Biol Psychiatry 2011;12:240–248.CrossRefGoogle ScholarPubMed
Claudino, A.M., Van den Eynde, F., Stahl, D., Dew, T., Andiappan, M., Kalthoff, J.et al.Repetitive transcranial magnetic stimulation reduces cortisol levels in bulimic disorders. Psychol Med 2010;7:1–8.Google Scholar
Fairburn, C.G.Eating Disorder Examination (Edition 16.0D) and Eating Disorder Examination Questionnaire (EDE-Q 6.0). In: Fairburn, C.G. editor. Cognitive therapy and eating disorders. New York, USA: Guildford Press; 2009. p. 265–3132009.Google ScholarPubMed
First, M.B., SpitzerRL, , Gibbon, M., Williams, J.B.W.Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I/P). New York: Biometrics Research, New York State Psychiatric Institute; 2002.Google Scholar
Garde, A.H., Hansen, A.M.Long-term stability of salivary cortisol. Scand J Clin and Lab Invest 2005;65:433–436.CrossRefGoogle ScholarPubMed
Henry, J.D., Crawford, J.R.The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. Br J Clin Psychol 2005;44:227–239.CrossRefGoogle Scholar
Israel, M., Steiger, H., Kolivakis, T., McGregor, L., Sadikot, A.F.Deep brain stimulation in the subgenual cingulate cortex for an intractable eating disorder. Biol Psychiatry 2010;67:53–54.CrossRefGoogle ScholarPubMed
Kamolz, S., Richter, M.M., Schmidtke, A., Fallgatter, A.J.Transcranial magnetic stimulation for comorbid depression in anorexia. Nervenarzt 2008;79:1071–1073.CrossRefGoogle ScholarPubMed
Kaye, W.H., Fudge, J.L., Paulus, M.New insights into symptoms and neurocircuit function of anorexia nervosa. Nat Rev Neurosci 2009;10:573–584.CrossRefGoogle ScholarPubMed
Keel, J.C., Smith, M.J., Wassermann, E.M.A safety screening questionnaire for transcranial magnetic stimulation. Clin Neurophysiol 2001;112(4):720.CrossRefGoogle ScholarPubMed
Klump, K.L., Bulik, C.M., Kaye, W.H., Treasure, J., Tyson, E.Academy for eating disorders position paper: eating disorders are serious mental illnesses. Int J Eat Disord 2009;42:97–103.CrossRefGoogle ScholarPubMed
Lovibond, P.F., Lovibond, S.H.The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. Behav Res Ther 1995;33:335–343.CrossRefGoogle ScholarPubMed
Marsh, R., Maia, T.V., Peterson, B.S.Functional disturbances within fronto-striatal circuits across multiple childhood psychopathologies. Am J Psychiatry 2009;166:664–674.CrossRefGoogle Scholar
Mond, J.M., Myers, T.C., Crosby, R.D., Hay, P.J., Rodgers, B., Morgan, J.F.et al.Screening for eating disorders in primary care: EDE-Q versus SCOFF. Behav Res Ther 2008;46:612–622.CrossRefGoogle ScholarPubMed
Schlaepfer, T.E., George, M.S., Mayberg, H.WFSBP Guidelines on Brain Stimulation Treatments in Psychiatry. World J Biol Psychiatry 2010;11:2–18.CrossRefGoogle Scholar
Slotema, C.W., Blom, J.D., Hoek, H.W., Sommer, I.E.Should we expand the toolbox of psychiatric treatment methods to include Repetitive Transcranial Magnetic Stimulation (rTMS)? A meta-analysis of the efficacy of rTMS in psychiatric disorders. J Clin Psychiatry 2010;71:973–984.CrossRefGoogle ScholarPubMed
Sternheim, L., Startup, H., Schmidt, U.An experimental exploration of behavioral and cognitive-emotional aspects of intolerance of uncertainty in eating disorder patients. J Anxiety Disord 2011;25:806–812.CrossRefGoogle ScholarPubMed
Uher, R., Brammer, M.J., Murphy, T., Campbell, I.C., Ng, V.W., Williams, S.C.et al.Recovery and chronicity in anorexia nervosa: brain activity associated with differential outcomes. Biol Psychiatry 2003;54:934–942.CrossRefGoogle ScholarPubMed
Uher, R., Yoganathan, D., Mogg, A., Eranti, S.V., Treasure, J., Campbell, I.C.et al.Effect of left prefrontal repetitive transcranial magnetic stimulation on food craving. Biol Psychiatry 2005;58:840–842.CrossRefGoogle ScholarPubMed
Van den Eynde, F., Broadbent, H., Guillaume, S., Claudino, A., Campbell, I.C., Schmidt, U.Handedness, repetitive transcranial magnetic stimulation and bulimic disorders. Eur Psychiatry 2010. http://dx.doi.org/10.1016/j.eurpsy.2010.08.015.CrossRefGoogle Scholar
Van den Eynde, F., Claudino, A.M., Horrell, L., Andiappan, M., Stahl, D., Schmidt, U.Cardiac safety of repetitive transcranial magnetic stimulation in bulimic eating disorders. Brain Stimul 2011;4:112–114.CrossRefGoogle ScholarPubMed
Van den Eynde, F., Claudino, A.M., Mogg, A., Horrell, L., Stahl, D., Ribeiro, W.et al.Repetitive transcranial magnetic stimulation reduces cue-induced food craving in bulimic disorders. Biol Psychiatry 2010;67(8):793–795.CrossRefGoogle ScholarPubMed
Van den Eynde, F., Treasure, J.Neuroimaging in eating disorders and obesity: implications for research. Child Adolesc Psychiatr Clin N Am 2009;18:95–115.CrossRefGoogle ScholarPubMed
van Kuyck, K., Gerard, N., Van Laere, K., Casteels, C., Pieters, G., Gabriels, L.et al.Towards a neurocircuitry in anorexia nervosa: evidence from functional neuroimaging studies. J Psychiatr Res 2009;43:1133–1145.CrossRefGoogle ScholarPubMed
Walpoth, M., Hoertnagl, C., Mangweth-Matzek, B., Kemmler, G., Hinterholzl, J., Conca, A.et al.Repetitive transcranial magnetic stimulation in bulimia nervosa: preliminary results of a single-centre, randomised, double-blind, sham-controlled trial in female outpatients. Psychother Psychosom 2008;77:57–60.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.