Case Series of the MonthReal-time Magnetic Resonance–guided High-intensity Focused Ultrasound Focal Therapy for Localised Prostate Cancer: Preliminary Experience
Section snippets
Case report
After institutional review board approval, we designed a feasibility study of magnetic resonance–guided focused ultrasound (MRgFUS) ablation in patients with localised prostate cancer (PCa; ClinicalTrials.gov ID: NCT01522118). All patients signed a dedicated informed consent. We enrolled a consecutive series of patients (Table 1) who had unifocal, biopsy-proven PCa evident on multiparametric magnetic resonance imaging (MRI). Patients with a Gleason score ≥8, multifocal or bilateral PCa with a
Discussion
Laser, cryoablation, radiofrequency ablation, microwave ablation, and photodynamic therapy have been extensively tested as focal therapies with reduced side-effects for treatment of localised PCa in select patients [3]. PCa ablation has been also successfully performed with high-intensity focused ultrasound under ultrasound guidance [4]. Featuring an accurate delivery of ultrasound energy to planned targets and real-time monitoring of tissue damage, MRgFUS has recently been developed and tested
Conflicts of interest
The authors have nothing to disclose.
EU-ACME question
Please visit www.eu-acme.org/europeanurology to answer the following EU-ACME question online (the EU-ACME credits will be attributed automatically).
Question:
What is the relationship between real-time magnetic resonance–guided focused ultrasound (MRgFUS) focal therapy for localised prostate cancer and radical prostatectomy (RP)?
- A.
MRgFUS determines a higher rate of complications following a radical retropubic prostatectomy.
- B.
MRgFUS does not influence the RP clinical outcome.
- C.
RP is contraindicated
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