CorrespondenceHuman chorionic gonadotropin inhibits insulin-like growth factor–binding protein-1 and prolactin in decidualized human endometrial stromal cells
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Acknowledgment
We thank Sebastian Wesselborg, Ph.D. (Department of Internal Medicine, University of Tübingen, Tübingen, Germany), for allowing us to use the ABI Prism 7000 sequence detector to perform the real-time RT-PCR measurements.
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2020, 100 Years of Human Chorionic Gonadotropin: Reviews and New PerspectivesGrass carp prolactin: Molecular cloning, tissue expression, intrapituitary autoregulation by prolactin and paracrine regulation by growth hormone and luteinizing hormone
2015, Molecular and Cellular EndocrinologyCitation Excerpt :Besides, PRL can also reduce LH release in vivo (e.g., in rat) by inhibiting GnRH pulsatility (Grattan et al., 2007) through down-regulation of kisspeptin neuronal system within the hypothalamus (Araujo-Lopes et al., 2014). In human endometrial cells, hCG secretion from implanted fetus can inhibit PRL expression after decidualization (Fluhr et al., 2006), but similar interaction between LH and PRL has yet to be examined at the pituitary level. In our studies, hCG treatment was found to down-regulate PRL secretion, cell content and total production with concurrent drop in PRL mRNA and primary transcript levels, whereas the reverse was true with removal of endogenous LH using LH antiserum (Fig. 8–9).
Does metformin influence the insulin-, IGF I- and IGF II-receptor gene expression and Akt phosphorylation in human decidualized endometrial stromal cells?
2011, European Journal of Obstetrics and Gynecology and Reproductive BiologyCitation Excerpt :In the present study we were able to demonstrate a direct effect of metformin on the activity of endometrial stromal cells, in analogy to Zhang and Liao, who demonstrated gene expression changes in endometriotic stromal cells in the presence of metformin [22]. The significant reduction of stromal cell decidualization capacity (reduced prolactin secretion) after 12–14 days metformin pretreatment, as seen prior [5] was similar to the influence of hCG during in vitro decidualization of human ESC, described by Fluhr et al. [23]. Human CG also decreases the expression and secretion of PRL in a dose- and time-dependent manner [23], suggesting that blastocyst secreted hCG, similar to exogenous metformin, influences endometrial differentiation by modulating the decidualization process.